摘要
目的 探究生化指标检测结果在妊娠期肝内胆汁淤积症（ICP）的诊断价值.方法 选取2015年1月至2016年1月本院收治的ICP产妇36例作为观察组,另外收集36名健康产妇作为对照组.回顾性分析两组孕妇的生化指标检测结果,并对存在显著性差异的指标进行诊断ICP敏感性、特异性、准确性的调查.结果 对照组与观察组相比较DB、血清总胆红素（TB）、碱性磷酸酶（ALP）、谷氨酰转移酶（GGT）、三酰甘油（TG）、乳酸脱氢酶（LDH）存在显著性差异（P〈0.05,t=8.231）,丙氨酸转氨酶（ALT）、门冬氨酸氨基转移酶（AST）、AST/ALT、总胆汁酸（TBA）存在显著性差异（P〈0.05,t=11.215）;总蛋白（TP）、清蛋白（ALB）、A/G、肌酸激酶（CK）、肌酸激酶同工酶（CKMB）、胆固醇（CHOL）差异无统计学意义（P〉0.05,t=0.856）,轻型ICP孕妇的TBA与重型ICP孕妇差异有统计学意义（P〉0.05,t=8.428）,;观察组与对照组孕妇对比存在显著性差异的生化指标对诊断ICP的敏感性、特异性、准确性进行研究,结果显示除TBA、ALT、ASTAST/ALT的敏感性、特异性、准确性较高外,其他小于等于50%.其中TBA对于轻度ICP和中度ICP的敏感性、特异性、准确性均较高.结论 生化指标中TBA.ALT,AST.AST/ALT可用作为ICP诊断的标准,而TBA则可以作为区分轻、重度ICP的标准,对于诊断ICP具有较高的临床价值.
Objective To explore the biochemical test results in intrahepatic cholestasis of pregnancy diagnosis;.Methods From January 2015 to January 2016,our hospital treated 36 cases of maternal ICP as the observation group,in addition to the collection of 36 healthy women as a control group.The biochemical indexes of two groups of pregnant women were analyzed retrospectively,and the sensitivity,specificity and accuracy of ICP were investigated.Results The control group and the observation group compared to DB,TB,ALP,GGT,TG,LDH had significant differences（P〈0.05,t=8.231）,there was significant difference of ALT,AST,AST/ALT,TBA（P〈0.05,t=11.215）;TP,ALB,A/G,CK,CKMB and CHOL was not significant the difference（P〉0.05,t=0.856）,there was significant difference between the TBA light ICP pregnant women with severe ICP（P〉0.05,t=8.428）,pregnant women;the observation group and the control group of pregnant women compared to the presence of significant differences in the biochemical indexes for the diagnosis of ICP sensitivity,specificity and accuracy were studied,results showed that except TBA,ALT,ASTAST/ALT the sensitivity,specificity,accuracy,the other is less than or equal to 50%.The sensitivity,specificity and accuracy of TBA for mild ICP and moderate ICP were higher.Conclusion TBA.ALT biochemical indexes,AST.AST/ALT to ICP as the standard of diagnosis,while TBA can distinguish between mild and severe ICP as the standard,the price is higher for the clinical diagnosis of ICP value.
作者
陈英
CHEN Ying(Department of Clinical Laboratory ,Changning Maternal and Child Health Care Hospital of Shanghai, Shanghai 200050, Chin)
出处
《检验医学与临床》
CAS
2017年第A01期87-90,共4页
Laboratory Medicine and Clinic
关键词
生化指标
妊娠期肝内胆汁淤积症
诊断
biochemical index
intrahepatic cholestasis of pregnancy
diagnosis
