摘要
肠黏液屏障是覆盖在肠上皮表面的由黏蛋白构成的凝胶型网状结构.MUC2是黏蛋白的主要成分,其特殊结构能保障黏液屏障的结构稳定性和抗性.杯状细胞能通过基础及调节分泌途径生成黏蛋白来维持和更新肠黏液层,肠道菌群也是黏液的组成、厚度及黏液屏障通透性功能形成的关键因素.肠黏液屏障能防止腔内细菌接触上皮,发挥抗感染作用,调节肠道免疫与外来刺激之间的平衡.而黏液屏障的结构和功能受损在感染性疾病、炎症性肠病、囊性纤维化、肿瘤等多种肠道疾病的发生发展中也起重要作用,或许会成为疾病治疗的新靶点.
The intestinal epithelium is coated by geMike network mucus layers composed of mucins.MUC2 is the main component of mucins, and it can maintain the structural stability and resistance of the mucus barrier. Mucins are continuously produced by Goblet cells through basic and regulated secretion. In this way, the mucus layers are replenished and the defense function is maintained, It has been reported that the properties of the mucus layers depend on the gut microbiota. The mucus layers are impervious to bacteria to protect the intestinal epithelium from unwanted substances and organisms. Recent studies suggest that the malfunction of the mucus barrier may play an important role in the development of many gastrointestinal diseases, such as infectious colitis, inflammatory bowel disease, cystic fibrosis, and colorectal tumors. Therefore, mucins might become a new target for the therapy of gastrointestinal diseases.
作者
李冰
于岩波
Bing Li Yan-Bo Yu(Department of Gastroenterology, Qilu Hospital of Shandong University, Ji＇nan 250012, Shandong Province, China)
出处
《世界华人消化杂志》
CAS
2017年第19期1764-1771,共8页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.NSFC81670486~~
关键词
肠黏液屏障
黏蛋白
杯状细胞
肠道菌群
Intestinal mucus barrier
Mucin
Goblet cells
Intestinal microbiota
