摘要
目的:探讨小剂量替勃龙治疗围绝经期综合征的临床疗效。方法:选取2014年5月—2016年5月鄂州市妇幼保健院诊治的围绝经期综合征患者140例,按照双盲随机数字表法分为对照组和观察组,每组70例。对照组患者给予替勃龙2.5 mg/d治疗,观察组患者给予替勃龙1.25 mg/d治疗,均连续治疗6个月。对比观察两组患者的总有效率、治疗过程中不良反应发生情况、治疗前后性激素水平等。结果:治疗后,观察组患者的总有效率为94.29%(66/70),明显高于对照组的84.29%(59/70),差异有统计学意义(P<0.05)。观察组患者不良反应发生率为7.14%(5/70),明显低于对照组的17.14%(12/70),差异有统计学意义(P<0.05)。治疗后,两组患者的性激素水平均明显改善,且观察组改善程度明显优于对照组,差异均有统计学意义(P<0.05)。结论:小剂量替勃龙治疗围绝经期综合征的疗效显著,且不良反应较少。
OBJECTIVE： To probe into the clinical efficacy of low-dose tibolone in treatment of women in perimenopausal syndrome. METHODS： 140 patients with perimenopausal syndrome admitted into Ezhou Maternal and Child Health Care Hospital from Apr. 2014 to Apr. 2016 were extracted to be divided into control group and observation group via the double blind random number table, with 70 cases in each. The control group was given tibolone 2.5 mg/d, while the observation group received tibolone 1.5 mg/d, for 6 months. The total effective rate, incidence of adverse drug reactions during treatment, level of sex hormones before and after treatment in two groups were compared and observed. RESULTS： After treatment, the total effective rate of observation group was 94.29% （66/70）, significantly higher than that of control group [ 84. 29% （59/70）], with statistically significant difference （P 〈0.05）. The incidence of adverse drug reactions in observation group was 7.14% （5/70）, significantly lower than that in control group [ 17. 14% （12/70）], with statistically significant difference（ P 〈0. 05 ）. After treatment, the level of sex hormones in both groups had been improved significantly, and the observation group was better than the control group, with statistically significant difference （P 〈 0. 05 ）. CONCLUSIONS ： The efficacy of low-dose tibolone in treatment of women in perimenopausal syndrome is significant with few adverse drug reactions.
出处
《中国医院用药评价与分析》
2017年第6期787-789,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
替勃龙
围绝经期综合征
小剂量
不良反应
Tibolone
Perimenopausal syndrome
Low dose
Adverse drug reactions
