摘要
目的观察脉血康胶囊(水蛭素)联合雌孕激素治疗血瘀型原因不明月经过少患者的临床疗效及作用机理。方法将入选的90例患者随机均分为治疗组(脉血康胶囊+雌孕激素)和对照组(雌孕激素),疗程3个月经周期内观察月经血量、血D-二聚体、血小板最大聚集率、子宫内膜厚度、螺旋动脉血流收缩期峰值流速PSV、阻力指数RI、搏动指数PI变化情况。结果两组治疗后月经量均增加(P<0.05),治疗组优于对照组(P<0.05);治疗组治疗后D-二聚体及血小板最大聚集率均较治疗前降低(P<0.05),对照组二者数值治疗后与治疗前比较无差异(P>0.05);两组治疗后的子宫内膜厚度均较治疗前增厚(P<0.05),但组间比较无显著差异(P>0.05);治疗组治疗后的RI值明显降低(P<0.05),而对照组治疗前后无明显变化(P>0.05);两组的PSV、PI数值治疗前后均无统计学差异(P>0.05)。结论脉血康胶囊与雌孕激素联合使用,可明显增加月经量,改善子宫血流灌注及子宫内膜微循环,比单独使用激素更具优势。
AIM To observe the clinical efficacy of Maixuekang Capsules（ hirudin） combined with female progestational hormone treating blood-stagnated cryptogenic hypomenorrhea and their mechanism of action.METHODS Ninty eligible patients were randomly and equally divided into treatment group（ Maixuekang Capsules combine with female progestational hormone） and control group（ female progestational hormone）,treated for three menstrual cycles,the menstrual blood volume,blood D-dimer,maximum platelet aggregation rate,the thickness of endometrium,spiral artery blood flow peak systolic velocity（ PSV）,resistance index（ RI） and pulsatility index（ PI） were recorded during the three months period. RESULTS The menstrual blood volume of the two groups were all increased post-treatments（ P〈0. 05）,the treatment group was superior to the control group（ P〈0. 05）; blood D-dimer and maximum platelet aggregation rate of the treatment group had reduced post-treatments（ P〈0. 05）,there was no difference in the two values of the control group between post-treatment and pre-treatment（ P〉0. 05）; the thickness of endometrium of the two groups were both increased after the treatment（ P〈0. 05）,while there was no remarkable statistical difference between the two groups（ P〉0. 05）; RI in the treatment group had remarkable reduction post-treatments（ P〈0. 05）,but there was no remarkable difference of RI in the control group（ P〉0. 05）; there was no statistical difference of PSV and PI in both groups before and after the treatment（ P〉0. 05）. CONCLUSION The combination treatment of Maixuekang Capsules and female progestational hormone can obviously increase menstrual blood volume,improve uterine blood perfusion and endometrial microcirculation. It has more advantages than use hormones alone.
出处
《中成药》
CAS
CSCD
北大核心
2017年第8期1582-1585,共4页
Chinese Traditional Patent Medicine
基金
广西中医药民族医药自筹经费科研课题(GZZC14-21)
关键词
脉血康
水蛭
月经过少
Maixuekang Capsules
hirudo
hypomenorrhea
