摘要
目的 评价心力衰竭（心衰）专用超滤设备治疗心衰的疗效和安全性.方法 入选2010年6月至2016年6月在新疆维吾尔自治区中医医院住院的心衰患者134例,利用SPSS 22.0软件产生随机序列号,将入选者按照1∶1的比例完全随机分为对照组和超滤组,每组67例.对照组采用强心、利尿（静脉推注呋塞米1 mg/kg）、扩血管等常规药物进行治疗.超滤组采用心衰专用超滤设备进行超滤治疗.对照组在治疗后8h评价疗效,超滤组在治疗后12 h评价疗效.观察两组患者治疗前后体重、呼吸困难评分及6 min步行距离以评价疗效.观察两组患者治疗前后收缩压、心率、血钠离子浓度、血钾离子浓度、血氯离子浓度、血pH值、血HCO3-、血红蛋白、血小板计数、血肌酐和血尿素氮以评价安全性.结果 （1）两组患者基线资料的比较：在临床治疗过程中对照组2例患者死亡,最终纳入132例,其中对照组65例,试验组67例.两组患者性别、年龄、心衰类型、呼吸困难评分和体重差异均无统计学意义.（2）两组患者疗效指标的比较：超滤组患者治疗后体重明显下降、呼吸困难评分和6 min步行距离均明显升高（P〈0.05）,且改善情况均优于对照组（P均〈0.05）.（3）两组患者安全性指标的比较：两组患者治疗前、后收缩压、心率、血钠离子浓度、血钾离子浓度、血氯离子浓度、血pH值、血HCO3-、血红蛋白、血小板计数、血肌酐和血尿素氮差异均无统计学意义.提示两种治疗方法安全性相当.结论 心衰超滤专用设备治疗心衰有效且安全.
Objective To evaluate the efficacy and safety of ultrafiltration in patients with heart failure.Methods One hundred and thirty four cases of patients with heart failure,who hospitalized in our hospital from June 2010 to June 2016 were enrolled in this study.Random serial number was generated using SPSS 22.0 software,patients were then randomly divided into control group and ultrafiltration group with the proportion of 1 ∶ 1 （67 cases in each group）.Patients in the control group received standard therapy.Patients in the ultrafiltration group received ultrafiltration therapy for 8 hours.Curative effect was evaluated after 8 hours treatment in the control group and after 12 hours in the ultrafiltration group.Following parameters were compared between the two groups：body weight,dyspnea score and 6 minutes walking distance as well as blood pressure,heart rate,Na＋,K＋,Cl-,pH,HCO3-,Hb,PLT,Cr,BUN levels.Results （1）Two patients died during run-in process and eventually 132 cases were chosen for final analysis （65 cases in control group and 67 cases in the ultrafiltration group）.Gender,age,type of heart failure,dyspnea score,body weight at baseline were similar between the two groups.（2）Post therapy,patients＇ body weight decreased obviously,while dyspnea score and 6 minutes walking distance increased significantly in the ultrafiltration group compared to baseline （all P 〈 0.05）,and the improvement was significantly greater compared to control group （all P 〈 0.05）.（3） The safety index comparison of two groups：blood pressure,heart rate,Na^＋,K^＋,Cl^-,pH,HCO3^-,Hb,PLT,Cr,and BUN were similar between the two groups at baseline and post therapy.Conclusion Ultrafiltration therapy is safe and effective to treat patients with heart failure.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
2017年第7期608-612,共5页
Chinese Journal of Cardiology
关键词
心力衰竭
超滤
治疗结果
Heart failure
Ultrafiltration
Treatment outcome
