摘要
目的探讨血必净对重症胰腺炎患者肾损伤的保护机制。方法将100例重症胰腺炎患者采用随机数字表法分为两组，各50例。两组均给予常规药物治疗，观察组联合血必净治疗，观察7d。比较两组患者的血尿素氮、血肌酐及24h尿量、白介素-6、血清C反应蛋白及肿瘤坏死因子a水平。结果治疗后两组血尿素氮及血肌酐水平显著低于治疗前（P〈0．01），24h尿量显著多于治疗前（P〈0．01），观察组较对照组变化更显著（P〈0．01）；观察组血清C反应蛋白、白介素-6及肿瘤坏死因子a水平，对照组血清C反应蛋白及白介素-6水平均较治疗前显著下降（P〈0．01），观察组较对照组下降更显著（P〈0．01）。结论血必净可有效降低重症胰腺炎患者的炎性反应，抑制炎性因子对肾毛细血管的损害作用，提高肾灌注量，保护肾功能，值得临床推广应用。
Objective To analyze the protection mechanism of Xuebijing on kidney injury in patients with severe acute panereatitis. Methods 100 patients with severe acute paneretitis were taken as the clinical re- search objects, and they were randomly divided into observation group （50 cases） and control group （50 cases）. Both groups were treated with routine medication, and the observation group was given additional Xuebijing. 7 days after treatment, the blood urine nitrogen （BUN）, serum creatinine （Scr） , 24h urine volume, IL-6, CRP, TNF-a of the two groups were compared. Results After treatment, BUN and Scr level in the two groups were significantly lower than before （P〈0. 01）, 24h urine volume was significantly higher than before （P〈0. 01）, observation group changed more significantly than control group （P〈0.01）; CRP, IL-6, TNF-a of observation group and CRP, IL-6 of control group were all declined significantly after treatment （P〈0.01）, observation group declined more significantly than control group （P〈0. 01）. Conclusion Xuebijing can effectively lower inflammatory reaction, inhibit adverse effect of inflammatory factor on renal capillaries, improve renal perfusion, protect renal function and is worthy of clinic promotion.
出处
《临床心身疾病杂志》
CAS
2017年第4期151-153,共3页
Journal of Clinical Psychosomatic Diseases
关键词
重症胰腺炎
血必净
肾功能
肾损伤
Severe pancreatitis
XueBi Jing injection
renal function
renal injury
