摘要
目的探讨真空负压垫联合热塑体膜在小儿肾母细胞瘤放疗中的临床应用价值。方法选取42例肾母细胞瘤术后接受放疗的小儿患者，依据体位固定方式的不同将其等分成A、B组，A组患者在放疗实施时采用真空负压垫固定体位，B组患者则采用真空负压垫联合热塑体膜固定体位。对比两组患者在治疗时的摆位误差、近期效果、不良反应以及预后。对计数资料行x2检验，计量资料行t检验。结果在平移误差、旋转误差、≤3mm和≤5mm的对比中B组均小于A组（P=0．04、0．04、0．04、0．03、0．00、0．04、0．04、0．00、0．04）；B组的完全缓解率、有效率均好于A组（P=0．02、0．04）；A组和B组的不良反应发生率相近（P=0．75）；A组和B组在2、3年0s率相近（P=0．68、0．74）。A组和B组在左右、头脚、腹背向外放值分别为5．74、5．93、5．94mm和4．21、5．71、4．61mm。结论对小儿肾母细胞瘤患者放疗时采取真空负压垫联合热塑体膜体位固定技术可降低摆位误差，提高放疗效果，值得在临床工作中推广和应用。
Objective To investigate the clinical value of negative pressure vacuum cushion combined with thermoplastic body membrane in radiotherapy for Wilms tumor in children. Methods A total of 42 pediatric patients with Wilms tumor who received radiotherapy after surgery were enrolled in the study and were randomly divided into two groups according to the fixation positions：group A and group B. During radiotherapy, the patients in group A were fixed with negative pressure vacuum cushion, and those in group B were fixed by negative pressure vacuum cushion combined with thermoplastic body membrane. The setup errors, short-term effects, adverse reactions, and prognosis were compared between the two groups. Results Group B showed significantly lower translational errors and rotational errors, as well as significantly higher rates of ~〈 3 mm and ~〈 5 mm errors, compared with the group A （ P = 0. 04,0. 04,0. 04,0. 03,0. 00,0. 04, 0. 04,0.00,0. 04）. Group B also showed significantly higher complete remission rates and response rates than group A （P= O. 02,0. 04）. There were no significant differences in the adverse reaction rates （P= 0. 75） and the overall survival （OS） rates at 2 and 3 years （P=0. 68,0. 74） between the two groups. Group A had the M pTv values in left-right （LR） direction （x-axis）, superior-inferior （SI） direction （y-axis）, and anterior-posterior （AP） direction （z-axis） being 5.74 mm, 5.93 mm, and 5.94 mm, respectively, and group B had the l^pTV values at LR, SI, and AP directions being 4.21 ram, 5.71 ram, and 4.61 ram, respectively. Conclusions In the radiotherapy positioning for Wilms tumor in children, fixation limbs with negative pressure vacuum cushion combined with thermoplastic body membrane effectively reduces the setup errors and improves the effect of radiotherapy, so it holds promise for clinical application.
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2017年第8期934-937,共4页
Chinese Journal of Radiation Oncology
关键词
肾母细胞瘤/放射疗法
真空负压垫
热塑体膜
治疗效果
不良反应
Wilms tumor/radiotherapy
Vacuum negative pressure pad
Thermoplastic body membrane
Treatment effect
Adverse reaction
