摘要
目的:探讨米诺环素对中重度慢性牙周炎合并2型糖尿病患者的临床指标、炎症因子和血糖的影响。方法:选取我院2013年2月-2015年8月收治的中重度慢性牙周炎合并2型糖尿病患者125例,按照随机数字表法分为对照组(63例)和观察组(62例)。两组患者均给予洁治术和根面平整术等牙周基础治疗;对照组患者术后给予碘甘油注满牙周袋,2~4次/d;观察组患者术后给予盐酸米诺环素软膏注满牙周袋,每周1次。两组患者均治疗4周。观察两组患者治疗前和治疗后3个月的临床指标[探诊深度、临床附着水平(CAL)和探诊出血率]、血清炎症因子(C反应蛋白和肿瘤坏死因子α)、血糖(空腹血糖和糖化血红蛋白)水平,并记录不良反应发生情况。结果:治疗前,两组患者临床指标、血清炎症因子和血糖水平比较,差异均无统计学意义(P>0.05)。治疗后3个月,两组患者探诊深度、探诊出血率和血清炎症因子水平均明显降低,且观察组明显低于对照组,差异均有统计学意义(P<0.05);两组患者CAL均较治疗前增加,但治疗前后比较、组间比较差异均无统计学意义(P>0.05);两组患者空腹血糖均明显降低,差异有统计学意义(P<0.05),但组间比较差异无统计学意义(P>0.05);对照组患者糖化血红蛋白水平较治疗前降低,但差异无统计学意义(P>0.05);观察组患者糖化血红蛋白水平明显降低,且观察组明显低于对照组,差异有统计学意义(P<0.05)。观察组患者不良反应发生率(3.23%)与对照组(0)比较,差异无统计学意义(P>0.05)。结论:米诺环素治疗中重度慢性牙周炎合并2型糖尿病可有效改善患者牙周炎的临床指标,降低血清炎症因子和血糖水平,且安全性较高。
OBJECTIVE：To investigate the effects of minocycline on clinical indexes,inflammatory factors and blood glucose of patients with moderate and severe chronic periodontitis complicated with type 2 diabetes（T2DM）. METHODS：A total of 125 patients with moderate and severe chronic periodontitis complicated with T2 DM selected from our hospital during Feb. 2013-Aug.2015 were divided into control group（63 cases）and observation group（62 cases）according to random number table. Both groups were periodental non-surgical treatment as scaling and root planning. Control group was given iodine glycerin to fill periodontal pockets after surgery,2-4 times/d. Observation group was given Minocycline hydrochloride ointment,once a week,after surgery.Both groups were treated for 4 weeks. The levels of clinical indexes [probing depth,clinical attachment level（CAL）,probingbleeding rate],serum inflammatory factors（CRP,TNF-α） and blood glucose（fasting blood glucose,glycosylated hemoglobin）were observed in 2 groups before treatment,3 months after treatment,and the occurrence of ADR was recorded. RESULTS：Before treatment,there was no statistical significance in clinical indexes,serum inflammatory factors and blood glucose levels between 2 groups（P〈0.05）. Three months after treatment,probing depth,probing bleeding rate and serum inflammatory factor levels of 2 groups were decreased significantly,and the observation group was significantly lower than the control group,with statistical significance（P〈0.05）. Compared to before treatment,CAL of 2 groups were increased,without statistical significance before and after treatment or between 2 groups（P〈0.05）. The levels of fasting blood glucose in 2 groups were decreased,with statistical significance（P〈0.05）,but no statistical significance between 2 groups（P〈0.05）. Compared to before treatment,the level of glycosylated hemoglobin in control group was decreased,without statistical significance（P〈0.05）;the level of glycosylated hemoglobin in observation group was decreased significantly,and the observation group was significantly lower than the control group,with statistical significance（P〈0.05）. There was no statistical significance in the incidence of ADR between observation group（3.23%） and control group（0）（P〈0.05）. CONCLUSIONS：For moderate and severe chronic periodontitis complicated with T2 DM,minocycline effectively improves clinical indexes of periodontitis,reduces serum inflammatory factors and blood glucose with good safety.
出处
《中国药房》
CAS
北大核心
2017年第23期3254-3257,共4页
China Pharmacy
关键词
米诺环素
慢性牙周炎
2型糖尿病
炎症因子
血糖
Minocycline
Chronic periodontitis
Type 2 diabetes
Inflammatory factor
Blood glucose
