脑苷肌肽注射液联合鼠神经生长因子注射剂治疗重症颅脑损伤的临床研究被引量：13

Clinical trial of cattle encephalon glycoside and ignotin injection combined with mouse nerve growth factor injection in the treatment of severe craniocerebral injury

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摘要目的观察脑苷肌肽注射液联合鼠神经生长因子注射剂治疗重症颅脑损伤的临床疗效及安全性。方法将80例重症颅脑损伤患者随机分作对照组40例与试验组40例。对照组予以脑苷肌肽注射液10 m L,静脉滴注,bid;试验组在对照组治疗的基础上,予以注射用鼠神经生长因子30μg,肌内注射,bid。2组患者均治疗4周。比较2组患者的临床疗效、神经功能缺损评分(NIHSS)和药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为95.00%(38/40例)和75.00%(30/40例),差异有统计学意义(P<0.05)。治疗后,试验组和对照组的NIHSS评分分别为(10.94±1.31)和(15.24±1.59)分,差异有统计学意义(P<0.05)。对照组发生的药物不良反应主要有头晕和烦躁,试验组发生的药物不良反应主要有局部疼痛和皮疹。试验组和对照组的药物不良反应发生率分别为7.50%和15.00%,差异无统计学意义(P>0.05)。结论脑苷肌肽注射液联合鼠神经生长因子注射剂治疗重症颅脑损伤的临床疗效确切,且不增加药物不良反应发生率。 Objective To observe the clinical efficacy and safety of cattle encephalon glycoside and ignotin injection combined with mouse nerve growth factor injection in the treatment of severe craniocerebral injury.Methods A total of 80 patients of severe craniocerebral injury were divided into control group and treatment group with 40 cases per group.Control group was treated cattle encephalon glycoside and ignotin injection 10 m L,intravenous drip,bid. Treatment group was given mouse nerve growth factor injection 30 μg,intramuscular injection,bid,on the basis of control group. Two groups were treated for 4 weeks. The clinical efficacy,neurological deficit score（ NIHSS）,and adverse drug reactions were compared between two groups. Results After treatment,the total effective rates in treatment and control groups were 95. 00%（ 38/40cases） and 75. 00%（ 30/40 cases） with statistically significant difference（ P〈0. 05）. After treatment,the NIHSS in treatment and control groups were（ 10. 94 ± 1. 31）,（ 15. 24 ± 1. 59） points, with significant difference（ P〈0. 05）. The adverse drug reactions in treatment group were local pain and rash,which in control group were dizziness andirritability. The incidences of adverse drug reactions in treatment and control groups were 7. 50% and 15. 00% without significant difference（ P〈0. 05）. Conclusion Cattle encephalon glycoside and ignotin injection combined with mouse nerve growth factor injection has a definitive clinical efficacy in the treatment of severe craniocerebral injury,without increasing the incidence of adverse drug reaction.

作者陆斌陈思

机构地区唐山工人医院神外一科

出处《中国临床药理学杂志》 CAS CSCD 北大核心 2017年第15期1397-1399,共3页 The Chinese Journal of Clinical Pharmacology

基金河北省医学科学研究重点课题计划基金资助项目(ZL20140228)

关键词脑苷肌肽注射液鼠神经生长因子注射剂重症颅脑损伤安全性 cerebroside inositol injection mouse nerve growth factor injection severe craniocerebral injury safety

分类号 R97 [医药卫生—药品]

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参考文献3

1杨玉玲,木冬妹,高岭燕,王智慧,林坚.鼠神经生长因子联合神经节苷酯对婴儿脑损伤后神经功能修复影响的临床研究[J].中国临床药理学杂志,2016,32(14):1265-1267. 被引量：23
2侯多凡,李广玉,王东成,侯宽省.重型颅脑损伤的诊断与治疗[J].实用儿科临床杂志,2005,20(1):80-81. 被引量：12
3脑卒中患者临床神经功能缺损程度评分标准（1995）[J].中华神经科杂志,1996,29(6):381-383. 被引量：15755

二级参考文献15

1刘晓帆,史新江,杜心顺,张卫兵,王仲伟.颅脑损伤后铁代谢的改变及其意义[J].新乡医学院学报,1995,12(3):244-247. 被引量：1
2TATARANNO M L, PERRONE S, BUONOCORE G. Plasma bio- markers of oxidative stress in neonatal brain injury[J]. Clin Perina- tol, 2015, 42(3) :529 -539.
3SUN J, QU Y, HE H,et al. Protective effect of polydatin on learn- ing and memory impairments in neonatal rats with hypoxicischemic brain injury by upregulating brainderived neurotrophic factor [ J ]. Mol Med Rep, 2014, 10(6) :3047 -3051.
4SMITH A L, HILL C A, ALEXANDER M,et al. Spatial working memory deficits in male rats following neonatal hypoxic ischemic brain injury can be attenuated by task modifications [ J ]. Brain Sci, 2014, 4(2) :240 -272.
5KOMUR M, OKUYAZ C, CELIK Y,et al. Neuroprotective effect of levetiracetam on hypoxic ischemic brain injury in neonatal rats[ J ]. Childs Nerv Syst, 2014, 30(6) :1001 -1009.
6YIN X, MENG F, WEI W,et al. Role of mouse nerve growth factor in neural recovery following hypoxic - ischemic brain damage [ J ]. lnt J Clin Exp Med, 2013, 6(10) :951 -955.
7SALMASO N, TOMASI S, VACCARINO F M. Neurogenesis and maturation in neonatal brain injury[ J]. Clin Perinatol, 2014, 41 ( 1 ) :229 - 239.
8GRANT P E, ROCHE - LABARBE N, SUROVA A, et al. Increased cerebral blood volume and oxygen consumption in neonatal brain injury [J]. J Cereb Blood Flow Metab , 2009, 29(10) :1704 -1713.
9YANG D, SUN Y Y, LIN X, et al. Taming neonatal hypoxic - is- chemic brain injury by intranasal delivery of plasminogen activator inhibitor- 1 [J]. Stroke, 2013, 44(9) :2623 -2627.
10XU L, LI Y, SHI X,et al. Expression, purification, and characte- rization of recombinant mouse nerve growth factor in Chinese hamster ovary cells [ J ]. Protein Expr Purif, 2014,104 ( 12 ) :41 - 49.