摘要
目的:探讨连续血浆滤过吸与连续血液透析在治疗脓毒血症中的临床效果。方法:选取入院治疗的脓毒血症患者80例随机分为研究组和对照组,每组40例。两组患者均给予脓毒血症基础治疗,研究组给予连续血浆滤过吸附,对照组给予连续血液透析。于治疗前后抽取采集患者的血标本,检测治疗前后两组患者的免疫细胞指标、炎症因子水平、APACHEⅡ评分和病死率统计,并进行比较分析。结果:两组治疗后各免疫水平均得到显著改善(P<0.05),然而研究组改善效果均显著优于对照组(P<0.05)。两组治疗后各炎症反应水平均得到显著改善(P<0.05),然而研究组改善效果均显著优于对照组(P<0.05)。两组治疗后的APACHEⅡ评分和病死率均存在统计学差异(P<0.05)。结论:连续血浆滤过吸附治疗在脓毒血症患者的血液净化治疗中效果更佳,具有临床应用价值。
Objective： To investigate the clinical effects of continuous plasma filtration with adsorption and continuous hematodialysis on improving the immune level of patients with sepsis in ICU. Methods： A total of 80 patients with sepsis were randomly divided into study group and control group, 40 patients in each group. All the patients were treated by routine treat- ment. Patients in study group were treated by continuous plasma filtration with adsorption and patients in control group were treated by continuous hematodialysis. The blood samples were collected before and after treatment. The immune cell level, inflammatory factors level, APACHE 1[ score and death rate were compared between two groups. Results- All immune cell in- dexes were significantly improved in both groups（P〈0. 05, P〈0. 01）. All immune cell indexes in study group were significantly better than those in control group, after treatment（P〈0.05, P〈0.01）. All inflammatory factors were significantly de- creased in both groups （P〈0.05, P〈0.01）. All inflammatory factors in study group were significantly better than those in control group, after treatment （P〈0.05, P〈0. 01）. The APACHE Ⅱ in study group was significantly better than that in control group, after treatment （P〈0.01）. The death rate in study group was significantly less than that in control group （P〈 0. 05）. Conclusion： Continuous plasma filtration with adsorption has a great clinical efficacy on patients with sepsis in ICU, which can improve the immune level and prognosis, makes it worth for clinical application.
作者
杨远征
胡志华
邓小彦
冼丽娜
YANG Yuan-zheng HU Zhi-hua DENG Xiao-yan XIAN Li-na(ICU, First Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, 570102)
出处
《海南医学院学报》
CAS
2017年第12期1627-1629,共3页
Journal of Hainan Medical University
关键词
脓毒血症
连续血浆滤过吸附
连续血液透析
免疫
临床效果
Sepsis
Continuous plasma filtration with adsorption
Continuous hematodalysis
Immune
Clinical effects
