摘要
目的观察盐酸戊乙奎醚注射液对急性有机磷中毒患者恢复时间的影响。方法将92例急性有机磷中毒患者随机分成观察组和对照组各46例。观察组患者采用盐酸戊乙奎醚注射液治疗,对照组患者采用阿托品治疗。对比2组患者的恢复时间、疗效及不良反应。结果观察组患者的临床症状消失时间、胆碱酯酶活性恢复时间及住院时间均显著短于对照组,差异均有统计学意义(P<0.01)。观察组患者的治疗有效率为93.48%明显高于对照组的71.74%,差异有统计学意义(P<0.01)。观察组患者的不良反应发生率为4.35%显著低于对照组的23.91%,差异有统计学意义(P<0.01)。结论盐酸戊乙奎醚注射液能有效缩短急性有机磷中毒患者的恢复时间,提高疗效,减少不良反应,是安全而有效的治疗药物。
Objective To observe the effects of penehyclidine hydrochloride on recovery time of patients with acute organic phosphorus poisoning.Methods 92 patients with acute organic phosphorus poisoning were randomly divided into observation group and control group,46 cases in each group.Observation group patients were treated with penehyclidine hydrochloride,and control group patients were treated with atropine.The recovery time,curative effect and adverse reactions between two groups were compared.Results The disappearance time of clinical symptoms,recovery time of cholinesterase activity and length of stay in observation group patients were distinctly shorter than those of control group,the differences were statistically significant（P〈0.01）.The treatment efficiency in the observation group（93.48%） was notably higher than that of control group（71.74%）,the difference was statistically significant（P〈0.01）.The rate of adverse reaction in observation group（4.35%） was apparently lower than that in control group（23.91%）,the difference was statistically significant（P〈0.01）.Conclusion The penehyclidine hydrochloride can availably shorten the recovery time,improve curative effect and reduce adverse reactions of patients with acute organic phosphorus poisoning.It is a safe and effective treatment.
作者
吴雷辉
WU Leihui(Department of Emergency, Liuzhou Worker＇s Hospital, Guangxi Zhuang Autonomous Region, Liuzhou 545005, Chin)
出处
《临床合理用药杂志》
2017年第16期8-9,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
盐酸戊乙奎醚注射液
急性有机磷中毒
恢复时间
疗效
不良反应
Penehyclidine hydrochloride
Acute organic phosphorus poisoning
Recovery time
Curative effect
Adverse reaction
