摘要
目的评价深部热疗配合顺铂腔内灌注化疗对晚期恶性肿瘤癌性胸腹腔积液患者的近期疗效及安全性。方法选取益阳市人民医院2014年2月~2016年2月期间收治的60例晚期恶性肿瘤合并胸腔或腹腔积液患者为研究对象,采用计算机随机数字法分为对照组(31例)和观察组(29例)。对照组仅给予顺铂60 mg·m^(-2)行胸腔或腹腔灌注,观察组在对照组的基础上于化疗后30 min行深部热疗,分析比较两组患者的疗效。结果观察组与对照组患者的治疗总有效率分别为75.86%和41.94%,差异有统计学意义(P<0.05)。观察组与对照组患者的生活质量好转率分别为68.97%和35.48%,差异有统计学意义(P<0.05)。两组均有部分患者出现Ⅰ~Ⅱ度毒副反应,对症治疗后缓解或消失,无一例患者因出现严重毒副反应而中止治疗。结论深部热疗联合顺铂腔内灌注化疗能显著改善晚期恶性肿瘤癌性胸腹腔积液患者的近期疗效及生活质量,安全性较好,值得临床推广应用。
Objective To evaluate the short-term efficacy and safety of deep hyperthermia combined with cisplatin perfusion chemo- therapy in treatment of advanced malignant pleural effusion. Methods 60 patients with advanced malignant tumor and pleura1 or peritoneal effusion admitted in our hospital between February 2014 and February 2016 were collected. They were divided into the control group （n=31） and the observation group （n=29） by computerized random number method. Patients in the control group received only cisplatin （60 mg.m-2） for thoracic or peritoneal perfusion, while those in the observation group were treated with deep hyperthermia for 30 min after chemotherapy. Results The total effective rates of the observation group and the control group were 75.86% and 41.94% respectively, and the difference was significant （P〈O.05）. The improvement rate of life quality of patients was 68.97% in the observation group but 35.48% in the control group, having significant difference （P 〈 0.05）. Some patients in the two groups had I ~ II degree of toxicity, which were relieved or disap- peared after symptomatic treatment. No patients had so severe side effects as to discontinue treatment in both two groups. Conclusion Deep hyperthermia combined with intracavitary chemotherapy of cisplatin can significantly improve the short-term efficacy and life quality of pa- tients with advanced malignancy or malignant pleural effusion, and the safety is good in the clinical application.
出处
《肿瘤药学》
CAS
2017年第4期421-424,435,共5页
Anti-Tumor Pharmacy
关键词
深部热疗
腔内灌注化疗
恶性胸腹水
近期疗效
生活质量
Deep hyperthermia
Intracavitary infusion chemotherapy
Malignant pleural effusion
Short-term curative effect
Quality of life
