摘要
目的探讨复方甘草酸单铵在急性髓系白血病患者化疗后肝损伤中的预防效果及对肝功能的影响。方法将100例急性髓系白血病患者按随机数字法分为对照组(n=50)和观察组(n=50)。对照组采用CAG化疗方案治疗,观察组在对照组的基础上联合复方甘草酸单铵治疗,采用全自动生化分析仪检测谷丙转氨酶(ALT)、直接胆红素(TBIL)及白蛋白(ALB)水平,比较两组患者的肝损伤发生率及对肝功能的影响。结果观察组治疗后ALT、TBIL及ALB水平均显著低于对照组(P<0.05);观察组化疗后WBC、HB、PLT水平均显著低于对照组(P<0.05),RBC水平则显著高于对照组(P<0.05);观察组化疗后1周、2周的肝损伤发生率均显著低于对照组(P<0.05)。结论急性髓系白血病患者采用化疗联合复方甘草酸单铵治疗可预防肝损伤,改善肝功能水平,值得临床推广应用。
Objective To investigate the preventive effect of compound Ammonium glycyrrhetat on hepatic dysfunction in patients with acute myeloid leukemia after chemotherapy and its influence on liver function. Methods A total of 100 patients with acute myeloid leukemia were randomly divided into control group （n=50） and observation group （n=50）. The control group was treated with CAG chemotherapy treat- ment, while the observation group was treated with compound Ammonium glycyrrhetate on the base of CAG chemotherapy. The glutamie- pyruvic transaminase （ALT）, direct biliruhin （TBIL） and albumin （ALB） level were detected by fully automatic biochemical analyser. Com- paring the deformity liver injury incidence and the effect on liver function of patients between the two groups. Results After treatment, the ALT, TBIL and ALB levels were lower in the observation group than in the control group （P〈O.05）. The WBC, HB and PLT levels were also lower in the observation group than in the control group （P〈0.05）. But the level of RBC was higher in the observation group than in the control group （P〈0.05）. The liver injury incidence rate was lower in the observation group than in the control group after one week even two weeks of chemotherapy （P 〈 0.05）. Conclusion The compound Glycyrrhizin combined with chemotherapy is helpful to prevent from the liver injury and improve the level of liver function in patients with acute myeloid leukemia. It is worth popularizing.
出处
《肿瘤药学》
CAS
2017年第4期451-454,498,共5页
Anti-Tumor Pharmacy
基金
四川省医学科研青年创新课题(Q14031)
泸州市科技计划项目(2016-S-67)
关键词
急性髓系白血病
复方甘草酸单铵
肝损伤
预防效果
肝功能
Acute myeloid leukemia
Compound glyeyrrhizin
Liver injury
Prevention effect
Liver function
