摘要
目的探讨黄芪加血府逐瘀汤加减治疗气虚血瘀型急性脑梗死的临床疗效及安全性。方法选取射阳县通洋中心卫生院2014年1月—2016年9月收治的气虚血瘀型急性脑梗死患者65例,按照随机数字表法分为对照组32例和观察组33例。对照组患者采用西医常规对症治疗,观察组患者在对照组基础上给予黄芪加血府逐瘀汤加减治疗,两组患者均持续治疗3个疗程。比较两组患者治疗前后中医症候积分及美国国立卫生研究院卒中量表(NIHSS)评分、临床疗效,观察患者不良反应发生情况。结果治疗前,两组患者中医症候积分、NIHSS评分比较,差异无统计学意义(P>0.05);治疗后,观察组患者中医症候积分、NIHSS评分低于对照组(P<0.05)。观察组患者治疗总有效率高于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论采用黄芪加血府逐瘀汤加减治疗气虚血瘀证急性脑梗死的临床疗效确切,可有效改善患者的神经功能,缓解临床症状,且安全性好。
Objective To investigate the clinical effect and the safety of astragalus membranaceus with xuefu zhuyu decoction modified in treating acute cerebral infarction. Methods A total of 65 cases of acute cerebral infarction patients were selected from January 2014 to September 2016 in Sheyang County Tong Yang Central Hospital,which were divided into control group（ n = 32） and observation group（ n = 33）. Control group was given conventional western medicine,observation group was treated with astragalus membranaceus with xuefu zhuyu decoction modified based on control group,both groups were treated for 3 courses. The TCM symptom scores and NIHSS scores before and after treatment,clinical effect were compared between the two groups,and the incidence of adverse reactions were observed of patients. Results Before treatment,no statistically significant differences of TCM symptom scores or NIHSS scores was found between the two groups（ P〉0. 05）; after treatment,the observation group of TCM symptom scores and NHISS scores were lower than control group（ P〈0. 05）. The total effective rate of observation group was higher than control group（ P〈0. 05）. There was no statistically significant difference of adverse reaction rate between the two groups（ P〉0. 05）. Conclusion Astragalus membranaceus with xuefu zhuyu decoction modified haven an exactly clinical effect in treating acute cerebral infarction,it can effectively improve neurologic function of patients,relieve clinical symptoms,and with good safety.
出处
《临床合理用药杂志》
2017年第21期14-15,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
脑梗死
血府逐瘀汤
黄芪
治疗结果
安全性
Brain infarction
Xuefu zhuyu decoction
Astragalus membranaceus
Treatment outcome
Safety
