摘要
目的探讨体检人群幽门螺杆菌(Helicobacter Pylori,HP)感染情况,以及血清中胃蛋白酶原I(PGI)、胃蛋白酶原Ⅱ(PGⅡ)和胃泌素-17(G-17)的含量与HP感染发生的相关性。方法研究纳入781例体检样本,分别用幽门螺杆菌抗体分型试剂盒和酶联免疫吸附实验对该人群行血清HP抗体分型,PGI,PGⅡ和G-17水平测定。运用SPSS22.0分析系统,分析该人群HP感染率,HP感染者与非感染者间及不同分型感染者间PGI,PGⅡ,PGI/PGⅡ(KPGR)和G-17水平差异,并对不同性别不同年龄分组体检者感染率及各水平差异进行分析。结果 HP阳性感染者占49.81%,不同性别间差异无统计学意义(X^2=0.284,P=0.594),不同年龄组间差异有统计学意义(X^2=8.523,P=0.014)。HP阳性与阴性者比较,血清中PGI,PGⅡ,PGR和G-17水平差异均有统计学意义(Z=8.616~14.125,均P=0.000)。HPⅠ型感染者和HPⅡ型感染者比较,血清PGⅡ和PGR水平差异有统计学意义(Z=3.444,3.385,均P=0.001)。不同性别血清中PGⅠ和PGⅡ水平差异有统计学意义(Z=5.012,4.478,均P=0.000),PGⅠ,PGⅡ水平男性较女性偏高;不同年龄组血清中PGⅠ,PGⅡ和PGR水平差异均有统计学意义(Z=2.086~4.614,均P<0.05),而G-17水平差异无统计学意义(Z=0.444~0.941,均P>0.05),随年龄升高,PGⅠ,PGⅡ和G-17有升高趋势,而PGR呈下降趋势。结论该地区体检人群中,血清PG水平与性别、年龄、HP是否感染有关,且与HP感染分型密切相关。将HP抗体分型及血清PG,G-17水平联合作为胃功能常规检测,对早期胃部疾病的筛查和评估有重要的意义。
Objective To investigate the infection status of Helicobacter pylori （HP） in the physical examination population and the contents of pepsinogen I （PGI）,pepsinogen II （PGII） and gastrin-17 （G-17） in serumand the association with HP infection. Methods In this study, 781 cases of physical examination were included. Serum HP antibody typing, PGI, PGII and G-17 were measured by Helicobacter pylori antibody kit and enzyme-linked immunosorbent assay. The levels of PGI, PGII,PGI/PGII and G-17 were analyzed by SPSS22.0 analysis system,and the difference of HP infection rate between HP infection group and non-infected patients and different types of infection was analyzed. Analysis of the infection rate and the difference of each age group. Results There was no significant difference between the two groups （2：0. 284 ,P=0. 594）, and there was significant difference between different age groups （x^2=8. 523 ,P=0. 014）. The levels of PGI,PGII,PGR and O-17 in serum were statistically significant （Z=8. 616-14. 125 ,P=0. 000） compared with those of HP positive and nega- tive. There were significant differences in serum PGII and PGR levels between HP I type and HP II type infection （Z 3. 444,3. 385,P=0. 001）. The levels of PGI and PGII in serum were significantly higher than those in other groups （Z= 5. 012,4. 478,P=0. 000）. PGI and PGII were higher in women than in females （Z=0. 444-0. 941,P〉0.05） ,with the in- crease of age,PGI,PGII and G-17 has an upward trend,while PGR showed a downward trend. Conclusion The level of serum PG was closely related to gender, age and HP infection, and was closely related to HP infection classification. The combi- nation of HP antibody typing and serum PG and G-17 as a routine test of gastric function is of great significance in the screening and evaluation of early gastric diseases.
出处
《现代检验医学杂志》
CAS
2017年第4期32-35,共4页
Journal of Modern Laboratory Medicine
基金
山东省自然科学基金(ZR2016HM52)
山东省临床重点专科项目(鲁卫医字[2013]26号)
山东省医药卫生重点实验室(鲁卫科教国合字[2013]49号)
