摘要
目的 评价自拟中药外洗方结合胸腺法新、异维A酸治疗多发性跖疣的疗效.方法 将符合入选标准的多发性跖疣患者120例,采用随机数字表法分为3组,每组40例.药物治疗组给予胸腺法新结合异维A酸治疗,联合中药外洗组在药物治疗组基础上结合自拟中药外洗方治疗,物理治疗组给予液氮冷冻治疗.3组均4周为1个疗程,共治疗3个疗程,随访3个月.比较3组治疗前后症状分级积分（皮损个数、皮损大小、疼痛程度及生活质量）,评价临床疗效,记录复发率.结果 治疗后12周,联合中药外洗组总有效率为97.5%（39/40）、药物治疗组为87.5%（35/40）、物理治疗组为90.0%（36/40）,联合中药外洗组总有效率高于药物治疗组及物理治疗组（Z值分别为-3.463、-3.122,P值分别为0.001、0.002）.治疗后,联合中药外洗组皮损个数[（2.0±1.1）分比（2.8±1.5）分、（2.7±1.6）分,F=3.787]、皮损大小[（2.3±1.7）分比（3.2±1.3）分、（3.1±1.3）分,F=4.657]、疼痛程度及生活质量[（0.4±0.5）分比（1.0±1.2）分、（1.0±1.0）分,F=5.353]评分均高于药物治疗组与物理治疗组（P〈0.01）.随访期间,联合中药外洗组复发率为10.3%（4/39）、药物治疗组为25.7%（9/35）、物理治疗组为41.7%（15/36）,3组复发率比较,差异有统计学意义（Z=-3.188,P〈0.01）.结论 自拟中药外洗方结合胸腺法新、异维A酸可减少多发性跖疣患者皮损个数、缩小皮损范围、降低疼痛程度,提高临床疗效.
Objective To evaluate the clinical effect of the homemade traditional Chinese medicine bathing prescription combined with Thymalfasin and Isotretinoin treatment for Verruca Plantaris.Methods A total of 120 patients with Verruca Plantaris were randomly divided into 3 groups according to the random number table method （each group 40）. The drug therapy group was given Thymalfasin and Isotretinoin to treatment; and the Chinese medicine washing group was given traditional Chinese medicine wash-out on the basis of drug therapy; and the physical therapy group was given liquid nitrogen freezing treatment on the basis of drug therapy. All the groups were treated 12 weeks and follow-up 3 months. Four weeks were a course, and a total of 3 courses. After the treatment, the symptom grading scores （number of skin lesions, the size of skin lesions, the degree of pain and the quality of life） was compared, and the clinical effect rate was evaluated and the recurrence rate was observed.Results Twelve weeks after treatment, Chinese medicine washing group total effective rate was 97.5% （39/40）, drug treatment group 87.5% （35/40）, and physical treatment group 90.0% （36/40）. The Chinese medicine washing group total effective rate was superior to the drug therapy and physical therapy groups （Z values were -3.463,-3.122,P values were 0.001, 0.002）. after treatment, the number of lesions scores （2.0 ± 1.1 vs. 2.8 ± 1.5, 2.7 ± 1.6,F=3.787）, the size of the lesion scores （2.3 ± 1.7 vs. 3.2 ± 1.3, 3.1 ± 1.3, F=4.657）, pain degree and the quality of life scores （0.4 ± 0.5 vs. 1.0 ± 1.2, 1.0 ± 1.0,F=5.353） in the Chinese medicine washing group were significantly higher than those in the drug therapy and physical therapy groups （P〈0.01）. After follow-up period, the recurrence rate of Chinese medicine washing group was 10.3% （4/39）, the drug treatment group 25.7% （9/35）, the physical therapy group 41.7% （15/36）. The difference among 3 groups was statistically significant （Z=-3.188,P〈0.01）.Conclusions The traditional Chinese medicine combined with Thymalfasin and Isotretinoin could reduce the number of skin lesions, narrow the range of skin lesions and reduce the degree of pain, and improve the quality of life.
出处
《国际中医中药杂志》
2017年第8期686-689,共4页
International Journal of Traditional Chinese Medicine
关键词
疣
跖
多发性
抗病毒药(中药)
薰洗
胸腺法新
异维A酸
临床研究
Warts
Metatarsus
Multiple
Antiviral drugs （TCD）
Steaming washing therapy
Thymalfasin
Isotretinoin
Clinical study
