摘要
目的 采用＂中医传承辅助平台（V2.0）＂软件,分析张士舜名老中医治疗食管癌的用药规律.方法 收集张士舜名老中医治疗食管癌的病案,录入＂中医传承辅助平台＂,采用频数分析、关联规则分析、改进互信息法等方法进行数据挖掘,确定处方中核心药物组合及药物间的关联规则等.结果 共收集166个处方,包含316味药物,其中使用频次较高的药物包括灵芝、通关藤、瓜蒌、冬凌草、姬松茸等;频次较高的药物组合包括＂灵芝、核桃枝＂＂山豆根、通关藤＂＂冬凌草、通关藤＂等.获得不同药物组合模式的关联规则11条.结论 张士舜主张辨病理、辨病位、辨证论治相结合治疗食管癌.强调标本兼顾,善用灵芝、核桃枝、姬松茸扶正,山豆根、通关藤、冬凌草祛邪,鸡内金、焦三仙顾护胃气,瓜蒌、薤白、银杏叶扩张食管,瓜蒌、黄芩引药入食管.
Objective To analyze the TCM principles of herbal prescriptions given by professor Zhang Shishun for esophageal cancer by using traditional Chinese medicine inheritance support system （V2.0）. Methods The herbal prescriptions from professor Zhang were collected and used for esophageal cancer, and then were recorded into the traditional Chinese medicine inheritance support system. The date mining methods were used such as principle analysis and revised mutual information. Results A total of 166 prescriptions for esophageal cancer were collected, which involved 316 Chinese medicines. The medicines with high frequency were Ganoderma, Caulis Marsdeniae Tenacissimae, Fructus Trichosanthis, Herba Rabdosiae Rubescentis, and Agaricus Blazei Murrill. The combinations of medicines included ＂Ganoderma and Ramulus Juglandis＂, ＂Radix et Rhizoma Sophorae Tonkinensis and Caulis Marsdeniae Tenacissimae＂, and ＂Herba Rabdosiae Rubescentis and Caulis Marsdeniae Tenacissimae＂. The prescription rules of drug combination mode were obtained. Conclusions The Professor Zhang advocated the theory of determination of treatment based on pathogenesis through differentiation of symptoms and signs, patho-examination, patho-location. He also stressed on the therapy of relieving both primary and secondary symptoms. The Ganoderma, Ramulus Juglandis and Agaricus Blazei Murril were used to strengthen the body resistance. Radix et Rhizoma Sophorae Tonkinensis, Caulis Marsdeniae Tenacissimae and Herba Rabdosiae Rubescentis were used to eliminate pathogenesis. The Endothelium Corneum Gigeriae Galli, Fructus Crataegi Praeparata, Massa Medicata Fermentata Praeparata were used to protect stomach-qi. The Fructus Trichosanthis, Bulbus Allii Macrostemonis and Folium Ginkgo were used to dilate the esophagus. The Fructus Trichosanthis was often combined with Radix Scutellariae to serve all medicines on the esophagus.
出处
《国际中医中药杂志》
2017年第8期710-713,共4页
International Journal of Traditional Chinese Medicine
基金
河北省中医约管理局2016年度科技计划课题（2016094、2016221）
关键词
方剂分析
计算机辅助
名医经验
张士舜
食管肿瘤
数据挖掘
用药规律
Formula analysis,computer assisted
Famous doctor＇s experience
Zhang Shishun
Esophageal neoplasms
Herbal administration experience
Data mining
Medication regularity
