摘要
自医药历史有记载以来,肿瘤一直是威胁人类生命健康的主要疾病,如何有效的治愈肿瘤也是当今医学领域中亟待解决的首要问题之一。中药复方是中国传统医学的瑰宝,其发展已有2 000多年的历史。以中医基础理论为指导运用中药复方治疗各种疾病古来有之。在中医病症中并无肿瘤一说,但通过对肿瘤的认识,分析其病机,可以将其归属于"癥瘕积聚"的范畴,由此可见,肿瘤治疗是中药复方临床应用的重要组成部分。在肿瘤治疗的过程中,中药复方能够充分调动机体的防疫机制,发挥多靶点、多层次、多环节的综合调控作用,在抑制肿瘤发生、发展,改善肿瘤患者的生活质量,延长生存期等方面具有显著优势。中药复方治疗强调整体观念,但由于其化学成分繁多、组方形式多样、药理机制复杂、干扰因素众多,目前对中药复方多环节、多靶点之间的相互联系和影响认识不够深入,以至于研究进展缓慢,国际认可程度较低。本文对近年来的相关文献进行收集、整理、归纳和总结,在抑制细胞增殖、诱导分化,影响细胞生长周期,诱导细胞凋亡,诱导细胞自噬,抑制端粒酶活性,抑制肿瘤的侵袭和转移,抑制血管生成,调节免疫状态等方面对中药复方抗肿瘤机制研究进行综述,为中医药防治肿瘤提供理论基础以及科学依据。
Since the medical history has been recorded,tumor is always a major disease which threats human life and health,and how to cure tumor effectively is still one of the most important problems in current medical field.Chinese medicinal formula is the treasure of traditional Chinese medicine（TCM）,and it has developed for over two thousand years.Application of Chinese medicinal formula in treating various diseases has a long history under the guide of TCM basic theory.There is no exact word for ＇tumor＇ in TCM,but based on the understanding of the pathogenesis of tumor,it can be classified into the category of ＇abnormal mass accumulation＇,thus,tumor therapy is an important part of clinical application of Chinese medicinal formula.In the process of tumor treatment,Chinese medicinal formula can fully mobilize the prevention mechanism of human body,play the comprehensive multi-target,multi-level and multi-link regulation effects,and has significant advantages in inhibiting tumor occurrence and development,improving the quality of life and prolonging the survival time of patients.Chinese medicinal formula treatment emphasizes the holistic concept,but because of its variety of chemical compositions,diversity of prescriptions,complexity of pharmacological mechanism and numerous interference factors,the understanding of the interrelation and influence between multi links and multi targets of Chinese medicinal formula is not deep enough.Therefore,the research progress is slow and the international recognition is low.In this paper,the related literature in recent years was collected,collated and summarized,with a researches review on mechanism of anti-tumor effects of Chinese medicinal formula and compound preparations in aspects of inhibiting cell proliferation,affecting cell cycle,inducing differentiation,apoptosis and autophagy,suppressing telomerase activity,tumor invasion and metastasis,controlling angiogenesis and regulating immune status.This paper could provide theoretical basis and scientific basis for prevention and treatment of tumors by TCM.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2017年第16期227-234,共8页
Chinese Journal of Experimental Traditional Medical Formulae
基金
上海中医药大学"名师工作室"专项(P20802)
关键词
中药复方
肿瘤
机制
研究进展
抗肿瘤
Chinese medicinal formula
tumor
mechanism
research progress
anti-tumor mechanism
