摘要
目的探讨甲氨蝶呤联合除湿化瘀汤治疗风湿性关节炎的临床疗效。方法选择医院2015年6月至2016年6月收治的风湿性关节炎患者128例,随机分为对照组与试验组,各64例。对照组患者采用甲氨蝶呤治疗,试验组患者在此基础上加用除湿化瘀汤治疗。结果试验组总有效率为92.19%,显著高于对照组的75.00%(P<0.05);试验组临床指标(如关节压痛、肿胀个数,晨僵时间及生化指标等)变化情况均显著优于对照组(P<0.05);试验组皮肤瘙痒、呕吐等不良反应情况发生率为6.25%,显著低于对照组的17.19%(P<0.01)。结论甲氨蝶呤联合除湿化瘀汤治疗风湿性关节炎,可显著改善关节肿胀、压痛、晨僵及各项生化指标,明显提高疗效及安全性,值得临床推广。
Objective To investigate the clinical effect of methotrexate combined with Chushihuayu Decoction in treating rheumatoid arthritis. Methods Totally 128 patients with rheumatoid arthritis from June 2015 to June 2016 admitted to our hospital were randomly divided into the control group and the experimental group,64 cases in each group. The control group was treated with methotrexate,on this basis,the experimental group was treated with Chushihuayu Decoction. Results The total effective rate of the experimental group was 92. 19%,which was significantly higher than 75. 00% of the control group（ P〈0. 05）. The changes of clinical indexes in the experimental group（ such as joint tenderness,number of arthroncus,morning stiffness and other biochemical indicators） were significantly better than those in the control group（ P〈0. 05）. The incidence rate of adverse reactions such as pruritus and vomiting in the experimental group was 6. 25%,which was significantly lower than 17. 19% of the control group（ P 0. 01）. Conclusion Methotrexate combined with Chushihuayu Decoction in the treatment of rheumatoid arthritis can significantly improve the arthroncus,joint tenderness,morning stiffness and other biochemical indicators,it can obviously improve the efficacy and safety,which is worthy of clinical promotion.
出处
《中国药业》
CAS
2017年第16期60-62,共3页
China Pharmaceuticals
关键词
甲氨蝶呤
除湿化瘀汤
风湿性关节炎
临床疗效
methotrexate
Chushihuayu Decoction
rheumatoid arthritis
clinical effect
