摘要
目的探讨小剂量低分子肝素钙用于原因不明复发性流产的临床疗效和安全性。方法对2014年1月至2016年11月在医院产科门诊保胎治疗、排除有明确病因的复发性流产患者105例进行研究,将其随机分为研究组50例和对照组55例,经尿检或血人绒毛膜促性腺激素(HCG)检测阳性,确诊为早期妊娠后,两组均给予地屈孕酮、维生素E及叶酸治疗。研究组在此基础上加用小剂量低分子肝素钙治疗,比较两组妊娠成功率、妊娠期并发症及药物不良发应情况。结果研究组妊娠成功率高于对照组,两组妊娠结局比较差异有统计学意义(P<0.05)。研究组妊娠期并发症发生率低于对照组,差异有统计学意义(P<0.05)。两组药物不良反应发生率比较差异未见统计学意义(P>0.05)。结论小剂量低分子肝素钙治疗不明原因复发性流产有较好的疗效,无明显药物不良反应,可安全使用。
Objective To investigate the clinical efficacy and safety of the small doses of low molecular weight heparin calcium for unexplained recurrent spontaneous abortion. Methods One hundred and five patients with recurrent spontane- ous abortion who received spuc therapy without clear pathogeny in hospital from January 2014 to November 2016 were researched. Fifty patients were randomly selected into the research group, 55 patients were randomly selected into the con- trol group. Early pregnancy was diagnosed when urine or blood human chorionic gonadotropin （HCG） test was positive. Both groups were given dydrogesterone, vitamin E and folic acid treatment. The research group was given the small doses of low molecular weight heparin calcium treatment in addition. Success rate of pregnancy, pregnancy complications and ad- verse drug reaction were compared between the two groups. Results The pregnancy success rate of the research group was higher than that of the control group, the pregnancy outcome was statistically different between the two groups （P 〈 0.05 ）. Pregnancy complication rate of the research group was lower than that of the control group, the difference was statistically significant （P 〈 0. 05 ）. Adverse drug reaction had no statistical difference between the two groups （P 〉 0. 05 ）. Conclusion The treatment of small doses of low molecular weight heparin calcium for unexplained recurrent spontaneous abortion is effective. This treatment has no obvious adverse drug reaction, and it can be used safely.
出处
《临床医学》
CAS
2017年第7期46-48,共3页
Clinical Medicine
关键词
低分子肝素钙
原因不明复发性流产
临床疗效
Low molecular weight heparin calcium
Unexplained recurrent spontaneous abortion
Clinical curativeeffect
