摘要
目的 利用动态对比增强MRI(DCE-MRI)的容积转移常数(Ktrans)定量评估胶质瘤Ki-67标记指数(Ki-67 labeling index,Ki-67 LI)的价值.方法 2014年1月至2016年1月搜集20例经常规病理确诊的胶质瘤患者,术前行颅脑DCE-MRI检查,利用动态对比增强专用血流动力学软件分析胶质瘤强化部分的Ktrans值,术后病理切片通过免疫组织化学方法检测Ki-67 LI,并分为高(>10%)、低(≤10%)两组,利用Spearman相关检验分析Ktrans值与胶质瘤Ki-67 LI之间的相关性,利用秩和检验(Mann-Whitney U检验)比较高、低Ki-67 LI两组间Ktrans值的差异.结果 胶质瘤Ktrans值[0.1252(0.0165~0.8048)]与Ki-67 LI[20%(5%~50%)]呈正相关(r=0.721,P<0.001);低Ki-67 LI组胶质瘤的Ktrans值[0.0697(0.0165~0.1456)]与高Ki-67 LI组的Ktrans值[0.1810(0.0810~0.8048)]差异有统计学意义(Z=-3.209,P=0.001);绘制ROC曲线,曲线下面积(AUC)为0.945,鉴别胶质瘤高、低Ki-67 LI的敏感度为92.3%,特异度为85.7%.结论 Ktrans值可用于定量评估胶质瘤Ki-67 LI.
Objective To study the value of transfer constant(Ktrans)derived from dynamic contrast-enhanced MRI (DCE-MRI) for quantitative evaluation of Ki-67 labeling index (Ki-67 LI) in glioma. Methods Twenty patients with glioma who underwent DCE-MRI and operation were retrospectively reviewed. The Ktrans value and Ki-67 LI were acquired and correlated using the Spearman correlation test. Also, the Ktrans values were compared between high(larger than 10%)and low(no more than 10%)Ki-67 LI group with Mann-Whitney U test, receiver operating characteristic curves was performed to evaluate the diagnostic value. Results The Ktrans value(0.0165 to 0.8048, median 0.1252)was significantly associated with Ki-67 LI(5%to 50%, median 20%) (r=0.721,P〈0.001), and the Ktrans value was significantly higher in high Ki-67 group(0.0810 to 0.8048, median 0.1810)than that in low Ki-67 LI group(0.0165 to 0.1456, median 0.0697)(Z=-3.209, P=0.001). The most predictive Ktrans value differentiated high Ki-67 LI and low Ki-67 LI with an area under the curve(AUC) of 0.945 at a sensitivity of 92.3% and specificity of 85.7%. Conclusion Ktrans value could be used for quantitative evaluation of Ki-67 LI in glioma.
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2017年第8期568-571,共4页
Chinese Journal of Radiology
基金
浙江省医药卫生科技计划项目(2016KYA104,2017KY374)