摘要
类风湿性关节炎中超过50%的患者死于心血管疾病,其心源性猝死的发生率是非类风湿性关节炎患者的2倍,且更易发生恶性室性心律失常。类风湿性关节炎致心律失常的机制可能是全身慢性炎症反应激活后,通过加速缺血性心脏病和充血性心力衰竭的发生发展,影响心脏电生理,从而促使心律失常的发生。因此,通过严格控制类风湿性关节炎疾病活动性以降低炎症负担,可能是减少类风湿性关节炎患者心律失常发生风险最有效的干预措施。
More than 50% Rheumatoid arthritis patients die from cardiovascular disease,and the incidence of sudden cardiac death for rheumatoid arthritis is 2times than non-RA patients.Rheumatoid arthritis is more likely to undergo malignant ventricular arrhythmia.Arrhythmia caused by rheumatoid arthritis might be due to the mechanism of systemic chronic inflammatory response activation,by accelerating the development of ischemic heart disease and congestive heart failure,affecting cardiac electrophysiology,prompting the occurrence of arrhythmia.Therefore,controlling the activation of rheumatoid arthritis strictly by reducing the burden of inflammation,could reduce the risk of arrhythmia for rheumatoid arthritis patients.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2017年第8期802-804,共3页
Journal of Clinical Cardiology
基金
国家自然科学基金重点项目(No:81530013)
