摘要
目的评价血清学指标β-HCG、孕酮及黄体血流动力学阻力指数(RI)及收缩期峰值流速(PSV)对异位妊娠的诊断价值。方法选择2015年5月至2016年7月本院收治的107例可疑早期异位妊娠患者为研究对象,根据最终确定的妊娠结局分为异位妊娠组(50例)和宫内妊娠组(57名)。比较两组受试者RI、PSV、β-HCG和孕酮指标,并分析ROC曲线下面积和相关性分析。结果异位妊娠组患者RI,显著高于宫内妊娠组受试者,PSV、β-HCG和孕酮均显著低于宫内妊娠组受试者,差异有统计学意义(P<0.01)。ROC曲线分析显示,RI、PSV、β-HCG和孕酮的AUC分别为0.652、0.877、0.714和0.959,且4项指标联合AUC可达0.987。相关性分析显示,PSV与孕酮的相关系数可高达0.576(P<0.01)。结论根据临床需求,4项指标联合检测可增加异位妊娠诊断的准确性。
Objective To evaluate the value of simultaneous determination of resistivity index, β-HCG and progesterone for diagnosis of ectopic pregnancy.Methods RI, PSV, serum β-HCG and progesterone were detected in patients with suspected early ectopic pregnancy in our hospital from May 2015 to July 2016. According to the final diagnosis they patients were divided into ectopic pregnancy （n= 50） and intrauterine gestation group （n = 57） T-test, ROC curve and correlation analysis were established.Results The RI in the ectopic pregnancy group was significantly higher than that in the intrauterine pregnancy group, and the PSV, beta -HCG and progesterone levels were significantly lower than those in the intrauterine pregnancy group, and the differences were statistically significant （P〈0.01）. ROC curve analysis showed that the AUC of RI, PSV, beta -HCG and progesterone were 0.652, 0.877, 0.714 and 0.959, respectively, and 4 indicators combined with AUC reached 0. 987. Correlation analysis showed that the correlation coefficient between PSV and progesterone could be as high as 0.576 （P〈0. 01 ）. Conclusions The sensitivity and specificity of the diagnosis of ectopic pregnancy could be increased when we combine with four indicators according to the clinical demand.
出处
《齐齐哈尔医学院学报》
2017年第13期1497-1499,共3页
Journal of Qiqihar Medical University
