摘要
目的 观察2型糖尿病合并微量白蛋白尿的患者予以骨化三醇治疗后,血糖、尿白蛋白与肌酐比值、胰岛β细胞功能的变化.方法 将60例2型糖尿病合并微量白蛋白尿的患者随机分为试验组及对照组各30例.试验组给予骨化三醇0.25 μg 1次/d的剂量连续治疗三个月.观察试验组和对照组血糖、糖化血红蛋白、尿白蛋白与肌酐比值、胰岛β细胞功能的变化.结果 干预后试验组的尿白蛋白与肌酐比值较对照组明显下降,差异有统计学意义[（127.48±139.94） mg/g与（151.02±96.25） mg/g,P=0.04].试验组较对照组的胰岛素抵抗指数有下降趋势,但差异无统计学意义（2.99±1.24与3.72±2.58,P=0.233）.结论 骨化三醇能够减少2型糖尿病患者的尿微量白蛋白.对改善2型糖尿病患者的胰岛素抵抗水平可能有帮助.
Objective To observe the changes in blood glucose,albumin/creatinine ratio and isletβcell function,after calcitriol therapy was used on patients with type 2 diabetes mellitus and microalbuminuria.Methods Sixty patients with type 2 diabetic microalbuminuria were randomly divided into experimental group and control group,each had 30 cases.Patients in the experimental group were given calcitriol 0.25ug once a day for three months,the changes of blood glucose,glycosylated hemoglobin,albumin/creatinine ratio,islet βcell function were observed.Results After the intervention,the albumin/creatinine ratio level in the experimental group was lower than that in the control group （（127.48±139.94） mg/g vs.（151.02±96.25） mg/g,P=0.04）.The insulin resistance index in the experimental group was lower than that in the control group （（2.99±1.24） vs.（3.72±2.58）,P=0.233）,the difference was not statistically significant.Conclusion Calcitriol can reduce microalbuminuria in patients with type 2 diabetes.Calcitriol may be helpful in improving insulin resistance in patients with type 2 diabetes mellitus.
出处
《中国综合临床》
2017年第7期610-614,共5页
Clinical Medicine of China
基金
上海市金山区卫计委资助项目（JSKJ-KTQN-2014-06）
