摘要
目的探讨肺表面活性物质(PS)对早产呼吸窘迫综合征(RDS)患儿外周血氧化应激产物及水通道蛋白(AQP)水平的影响。方法选取2015年1月-2016年12月在该院出生且住院治疗的早产RDS患儿160例,按照治疗方式的不同分为两组:80例应用PS治疗为观察组,80例未应用PS治疗为对照组。比较两组的临床转归及并发症,治疗前后检测两组的外周血丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、AQP-1、AQP-5水平。结果观察组治疗总有效率为97.50%,显著高于对照组的85.00%(P<0.05);观察组的机械通气时间、总氧疗时间及住院时间均较对照组明显缩短(P<0.05);治疗后观察组血清MDA、AQP-1及AQP-5显著低于对照组,SOD、GSH-Px显著高于对照组(P<0.05);治疗后观察组的动脉血二氧化碳分压(PaCO_2)显著低于对照组,动脉血氧分压(PaO_2)、动脉血氧合指数(PaO_2/FiO_2)显著高于对照组(P<0.05);观察组脑室内出血(IVH)及肺炎发生率显著低于对照组(P<0.05)。结论 PS辅助治疗早产儿RDS能够保护肺呼吸功能,抗氧化应激反应及下调血清AQP表达可能是其作用机制之一。
Objective To explore the effect of pulmonary surfactant（ PS） on serum oxidative stress products and aquaporin（ AQP）level of premature infants with respiratory distress syndrome（ RDS）. Methods A total of 160 premature infants with RDS were selected from the hospital from January 2015 to December 2016,then they were divided into observation group（ including 80 premature infants treated by PS） and control group（ including 80 premature infants not treated by PS） according to the therapeutic method. The clinical outcomes and complications in the two groups were compared; the levels of malondialdehyde（ MDA）,superoxide dismutase（ SOD）,glutathione peroxidase（ GSH-Px）,AQP-1,and AQP-5 in peripheral blood were detected before and after treatment in the two groups. Results The total effective rate in observation group was 97. 50%,which was statistically significantly higher than that in control group（ 85. 00%）（ P 0. 05）; the duration time of mechanical ventilation,the total oxygen inhalation time,and hospitalization time in observation group was statistically significantly shorter than that in control group（ P〈0. 05）; after treatment,the levels of serum MDA,AQP-1,and AQP-5 in observation group were statistically significantly lower than those in control group,while the levels of serum SOD and GSH-Px were statistically significantly higher than those in control group（ P〈0. 05）; after treatment,arterial partial pressure of carbon dioxide（ PaCO2） in observation group was statistically significantly lower than that in control group,while arterial partial pressure of oxygen（ PaO2） and arterial blood oxygenation index（ PaO2/FiO_2） were statistically significantly higher than those in control group（ P〈0. 05）; the incidence rates of intraventricular hemorrhage and pneumonia in observation group were statistically significantly lower than those in control group（ P〈0. 05）. Conclusion PS can protect pulmonary respiratory function of premature infants with RDS,anti-oxidative stress response and down-regulation of serum AQP expression may be the mechanisms.
出处
《中国妇幼保健》
CAS
2017年第16期3836-3840,共5页
Maternal and Child Health Care of China
