摘要
目的了解狂犬病暴露者接种疫苗后的不良反应,为减少不良反应的发生以及狂犬病疫情的防控提供参考依据。方法采取当面观察、询问与电话追踪相结合的办法,对接种狂犬病疫苗的暴露病例进行疑似预防接种异常反应(AEFI)监测调查。结果在3 365例狂犬病暴露病例中监测到AEFI 49例次,所有AEFI均为不良反应,发生率为364.75/10万剂。AEFI病例在时间(χ~2=12.222)、空间(χ~2=1.266)及性别(χ~2=0.624)中的分布差异均无统计学意义(P>0.05);在年龄组(χ~2=10.800)与暴露级别(χ~2=6.352)中的分布差异均有统计学意义(P<0.05)。结论接种狂犬病疫苗后的不良反应总体上数量少、症状轻,以一般反应为主。无佐剂人用狂犬病疫苗(Vero细胞)具有良好的安全性。
Objective To understand the adverse reactions of rabies exposed persons after vaccination,to provide references for reducing the incidence of adverse reactions and prevention and control of rabies. Methods Adverse Events Following Immunization（ AEFI） surveillance survey was conducted on the exposed cases of inoculated rabies vaccine by means of a combination of face-to-face observation and inquiry and telephone tracking. Results In 3365 cases of rabies exposure,49 cases of AEFI were monitored,all of which were adverse reactions,with rate of 364. 75/100000. In the case of AEFI there were no statistically significant in the time（ χ~2= 12. 222）,space（ χ~2= 1. 266） and gender（ χ~2= 0. 624）（ P〉0. 05）; there were statistically significant differences in the age group（ χ~2= 10. 800） and the level of exposure（ χ~2= 6. 352）（ P〈0. 05）.Conclusion After vaccination,the adverse effects of rabies vaccine are small and mild in general. Non adjuvant Purified Hamster Kidney Cell Rabies Vaccine（ Vero） cells have good safety.
出处
《中国公共卫生管理》
2017年第4期508-509,513,共3页
Chinese Journal of Public Health Management
基金
2014年缙云县科技计划项目(201441)
关键词
狂犬病疫苗
不良反应
调查
rabies vaccine
adverse reactions
research
