摘要
采用UPLC-Q-TOF MS^E技术结合UNIFI数据库对黄柏的化学成分进行了快速鉴定。根据UNIFI数据库,进行数据筛查,对于已知成分依据其精确分子质量、特征离子、质谱裂解规律、色谱保留时间等信息并结合文献报道对其进行验证。本实验共鉴定出15个化合物,对黄柏药材中的化学成分进行快速分析,为黄柏的质量控制和药效物质基础研究奠定基础,并为全面表征黄柏指纹图谱提供依据。本研究提供了有效的数据处理策略,快速描述了草药提取物的化学成分。
The chemical composition of Cortex Phellodendri was rapidly identified by UPLC-Q-TOF MS^E technique combined with UNIFI database. According to the UNIFI database,data were screened,and the known components were validated according to their precise molecular weight,characteristic ion,mass spectrometry lysis and chromatographic retention time. 15 compounds were identified,including the rapid and comprehensive analysis of the chemical constituents in the medicinal materials of Cortex Phellodendri,and the foundation for the quality control and pharmacological basis of Cortex Phellodendron was laid. This study provided an efficient data processing strategy to rapidly profile the chemical constituents of complicated herbal extracts.
出处
《广州化工》
CAS
2017年第16期105-107,共3页
GuangZhou Chemical Industry
基金
贵州省科技厅联合基金(黔科合LH字[2015]7340)
贵州省科技厅中药现代化项目(黔科合ZY字[2013]3016)
贵州省普通高等学校药物化学工程研究中心建设项目(黔教合KY[2014]219)
