摘要
目的研究阿立哌唑联合氯氮平治疗难治性精神分裂症对患者代谢综合征(MS)的影响。方法将90例以阴性症状为主的难治性精神分裂症患者随机分为阿立哌唑联合氯氮平组(A组)、单独使用氯氮平组(B组)及单独使用阿立哌唑组(C组)。分别在治疗4周、8周、12周末使用阳性与阴性症状量表(PANSS)评价疗效,用副反应量表(TESS)评价不良反应并对比三组药物对患者MS的影响。结果 A组总体MS发生率低于B组,差异有统计学意义(P<0.05),而与C组比较差异无统计学意义(P>0.5)。三组间TESS评定结果比较差异无统计学意义(P>0.5)。结论阿立哌唑联合氯氮平对精神分裂症患者代谢指标的影响较氯氮平小,并能明显改善患者的阴性症状。
Objective To study the effect of aripiprazole combined with clozapine on metabolic syndrome（MS） in patients with refractory schizophrenia.Methods 90 patients with negative symptoms of patients with refractory schizophrenia were randomly divided into aripiprazole combined with clozapine group（A group）,the use of clozapine alone group（B group） and single aripiprazole group（C group）.The positive and negative symptom scale（PANSS） was used to evaluate the curative effect at 4 weeks,8 weeks and 12 weekends,and the adverse effects were evaluated by the side reaction scale（TESS）,and the effects of 3 groups of drugs on the MS of patients were compared.Results The overall incidence of MS in group A was lower than that in group B,the difference was statistically significant（P〈0.05）,but there was no significant difference between group C and group（P〉0.5）.Except MS,there was no significant difference in the overall side effects between group A and group B and group C（P〉0.5）.Conclusion Aripiprazole has less influence on the metabolic indexes of schizophrenics than clozapine,and can obviously improve the negative symptoms in patients with schizophrenia.
出处
《继续医学教育》
2017年第8期150-152,共3页
Continuing Medical Education
