摘要
目的观察中药治疗伴失眠的肝郁阴虚型干眼病临床疗效。方法 40例(80只眼)伴失眠的肝郁阴虚型干眼病患者,随机分为对照组和治疗组,各20例(40只眼)。对照组以聚乙二醇滴眼液点眼,治疗组以聚乙二醇滴眼液点眼的同时口服中药柴胡疏肝散合生脉散加减治疗,服药后15、30 d及停药30 d分别进行基础泪液分泌试验(ST)表面麻醉、泪膜破裂时间(BUT)、角膜荧光素染色等检查评价疗效。结果服药15、30 d,治疗组的BUT和ST表面麻醉总有效率高于对照组,差异有统计学意义(P<0.05)。停药30 d,治疗组BUT和ST表面麻醉的总有效率分别为78%、73%,均高于对照组的40%、43%,差异有统计学意义(P<0.05)。结论中药治疗伴失眠的肝郁阴虚型干眼病效果良好,方药安全,值得临床推广应用。
Objective To observe the clinical efficacy of traditional Chinese medicine in the treatment of insomnia with liver yin deficiency type dry eye disease.Methods A total of 40（80 eyes） insomnia with liver yin deficiency type dry eye disease patients were randomly divided into control group and treatment group,with 20（40 eyes） in each group.The control group received polyethylene glycol eye drops for eye drops,and the treatment group received polyethylene glycol eye drops for eye drops and oral Chaihu Shugan powder and Shengmai Powder addition and subtraction.After 15 and 30 d of administration and 30 d of drug withdrawal,the basal tear secretion test（Schirmer test,ST） surface anesthesia,tear film break-up time（BUT） and corneal fluorescein staining were performed to evaluate the efficacy.Results After 15 and 30 d of administration,the treatment group had higher BUT and total effective rate of ST surface anesthesia than the control group,and their difference had statistical significance（P〈0.05）.After 30 d of drug withdrawal,the treatment group had BUT and total effective rate of ST surface anesthesia respectively as 78% and 73%,which were all higher than 40% and 43% in the control group,and their difference had statistical significance（P〈0.05）.Conclusion Traditional Chinese medicine shows good effect in the treatment of insomnia with liver yin deficiency type dry eye disease with safe prescription,and it is worthy of clinical promotion and application.
出处
《中国实用医药》
2017年第22期108-110,共3页
China Practical Medicine
关键词
中药
干眼病
失眠
肝郁阴虚
Traditional Chinese medicine
Dry eye disease
Insomnia
Liver yin deficiency
