摘要
目的研究2015和2016年河南省食源性疾病患者中沙门氏菌的感染情况、血清型分布、病因性食品来源和耐药趋势。方法从河南省15家哨点医院中,采集符合病例定义的病人5 720份暴露食品信息,从粪便中分离到221株沙门氏菌,进行了血清分型、耐药性研究和相关的病因性食品溯源等研究,并对结果进行了统计分析。结果 221株沙门氏菌血清学以肠炎沙门氏菌、鼠伤寒沙门氏菌和汤卜逊沙门氏菌为主导菌型,且广泛分布于46个血清型,菌型呈现多态性分布;可疑病因性食品的种类以乳与乳制品和肉与肉制品为主;在11种抗生素的药物敏感试验中,沙门氏菌对头孢西丁、头孢噻圬、氯霉素和甲氧苄氨嘧啶/磺胺甲恶唑4种抗生素的敏感率下降(P<0.05),对头孢他啶、氨苄西林、四环素和氨苄西林/舒巴坦的敏感率下降(P<0.01),只有对环丙沙星、萘啶酸和庆大霉素的敏感率下降无统计学意义(P>0.05)。结论相关部门应加强对肉与肉制品的市场监管力度,加大对抗生素药物使用的管理力度,加强沙门氏菌疾病和耐药性的主动监测,减少食源性疾病的发生。
We investigated the infection situation,serotype distribution,sources of etiological food and drug resistance of Salmonellain foodborne disease patients in Henan Province in 2015 and 2016.We evenly arranged 15 sentinel hospitals in Henan Province in 2015 and 2016,and a total of 5 720patient-defined cases were monitored,whose information was collected.A total of 221 Salmonellastrains were isolated from the fecal of diarrhea patients,who were studied on serotyping,drug resistance and traceability of related etiological food,and the results were analyzed statistically.Results showed that the S.enteritidis,S.typhimuriumand S.thompson were dominant types for serotyping in the 221 Salmonellastrains,and 221 strains were widely distributed in 46 serotypes,the serotype distribution was more extensive;dairy and dairy products and meat and meat products were main suspicious etiological foods types caused by Salmonella.For drug susceptibility test of 11 kinds of antibiotics,the susceptibility of Salmonellato Cefoxitin,Cefotaxime,Chloramphenicol and Trimethoprim/Sulfamethoxazole significantly decreased（P〈0.05）,and that to Ciprofloxacin,Ampicillin,Tetracycline and Ampicillin/Sulbactam decreased significantly（P〈0.01）;only that to Ciprofloxacin,Nalidixic acid and Gentamicin decreased insignificantly（P〈0.05）.Relevant departments should strengthen the meat and meat products market supervision,to make great efforts for control the use of antibiotics,strengthen the active surveillance of Salmonelladisease and drug resistance,and to reduce the incidence of foodborne diseases.
出处
《中国人兽共患病学报》
CAS
CSCD
北大核心
2017年第8期748-752,共5页
Chinese Journal of Zoonoses
基金
河南省科技攻关项目(No.162102310310)~~
