摘要
人体肠道内寄生着大量细菌,其中大部分为对人体有危害的致病菌,而肠黏膜具有阻挡这些细菌入侵机体的屏障功能。但其屏障功能受损时,肠黏膜通透性增加,肠道细菌、内毒素等有害物质失控地逸出至肠腔外组织中,引发一系列病理生理改变,甚至触发全身炎症反应综合征、多器官功能障碍综合征。因此,早期、有效地评估肠屏障功能状态对肠屏障功能受损导致的肠道菌群移位及肠源性感染、改善危重患者的预后有重要意义。近年来,一些与肠屏障功能受损相关的标志物相继被报道,未来希望能将基础实验筛查出来的评估指标更多的应用于临床。
The human body is parasitic with a large number of bacteria, most of which are harmful pathogens to the human body, and intestinal mucosa has the function to block bacteria invasion into the body. But when the barrier function is damaged, there may be increased intestinal mucosal permeability,intestinal bacteria, endotoxin and other harmful substances maybe out of control to escape to the intestine tissue, triggering a series of pathophysiological changes, and even trigger systemic inflammatory response syndrome, multiple organ dysfunction syndrome. Therefore, there is a great significance to assess tbe intestinal barrier function earlier and effectively for critically ill patients with intestinal barrier dysfunction caused intestinal flora shift and intestinal infection. In recent years, some of the markers associated with impaired bowel barrier function have been reported, and in the future ,we hope that the evaluation indicators based on the basic experiment screening will be more applied to the clinical.
出处
《医学综述》
2017年第17期3348-3353,共6页
Medical Recapitulate
基金
基金项目:云南省院士专家工作站杨桦专家工作站(2015IC034)
关键词
肠屏障功能受损
肠源性感染
标志物
Intestinal barrier dysfunction
Gut derived infection
Biomarkers
