摘要
目的:分析丹参多酚酸盐联合左卡尼汀治疗稳定型心绞痛患者的临床疗效。方法:126例稳定型心绞痛患者按照数字表法随机分成两组。对照组63例仅给予左卡尼汀治疗,观察组63例在左卡尼汀治疗基础上联合应用丹参多酚酸盐。比较两组肌钙蛋白、超敏C反应蛋白、心电图改善情况、不良反应以及心功能各项指标。结果:观察组c Tn I(0.56±0.33)μg/L、hs-CRP(2.79±0.66)mg/L、LVEF(51.23±4.92)%、E/A(1.16±0.43)、心电图改善总有效率(98.41%)明显优于对照组c Tn I(0.72±0.28)μg/L、hs-CRP(3.05±0.43)mg/L、LVEF(49.18±4.34)%、E/A(0.95±0.24)、心电图改善总有效率(85.71%),差异有统计学意义(P<0.05)。两组用药不良反应无显著差别(P>0.05)。结论:稳定型心绞痛患者采用丹参多酚酸盐及左卡尼汀联合治疗,能够扩张血管,改善心功能,减少心绞痛发作次数,有助于控制病情发展,满足患者期望值。
Objective： To evaluate the clinical effect of salvianolate combined with L-carnitine in treatment of patients with stable angina pectoris. Methods： A total of 126 patients with stable angina pectoris were randomly divided into two groups according to the digital table method. Sixty-three patients in the control group were given L-carnitine treatment and the other 63 patients in the observation group were given salvianolate combined with L-carnitine. Cardiac troponin,high-sensitivity C reactive protein,ECG improvement,adverse reactions and cardiac function were compared. Results：The observation group＇s c Tn I（ 0. 56 ± 0. 33） g/L,hs-CRP（ 2. 79 ± 0. 66） mg/L,LVEF（ 51. 23 ± 4. 92） %,E/A（ 1. 16 ± 0. 43）,electrocardiogram improved total efficiency rate（ 98. 41%） were significantly better than c Tn I（ 0. 72 ±0. 28） g/L,hs-CRP（ 3. 05 ± 0. 43） mg/L,LVEF（ 49. 18 ± 4. 34） %,E/A（ 0. 95 ± 0. 24）,electrocardiogram and improved total efficiency（ 85. 71%） of the control group and the difference was statistically significant（ P〈0. 05）.There was no significant difference in adverse drug reactions between two groups（ P〉0. 05）. Conclusion： The salvianolate combined with L-carnitine can dilate blood vessels,improve heart function,reduce the frequency of angina pectoris patients,contributing to the development of disease control to meet the expectations of patients.
出处
《中华中医药学刊》
CAS
北大核心
2017年第9期2404-2406,共3页
Chinese Archives of Traditional Chinese Medicine
基金
海南省自然科学基金项目(20168293)
