摘要
目的:研究分析骨氏葆方与膝关节内粘疗法联合治疗对肾虚血瘀型膝重度骨关节炎功能的治疗效果与安全性。方法:肾虚血瘀型膝重度关节炎患者100例,按照随机数字表法将其分为治疗组和对照组各50例,两组患者均给予膝关节内粘疗法和健康教育等基础治疗,在此基础上给予对照组患者口服盐酸氨基葡萄糖胶囊进行治疗,给予治疗组患者骨氏葆方进行治疗,连续治疗5周后观察比较两组患者的治疗效果,并应用中医症状评分标准对两组患者的临床症状进行评分,同时监测两组患者在治疗前后的骨型碱性磷酸酶、降钙素和血沉的变化状况。结果:治疗后两组患者的血沉均显著降低(P<0.01),且治疗组患者的降低程度显著优于对照组(P<0.05),差异有统计学意义。但两组患者的降钙素和骨型碱性磷酸酶均无改善,其差异无统计学意义(P>0.05)。治疗后两组患者的主要症状和体征积分均显著降低(P<0.05),且治疗组患者的改善程度显著优于对照组(P<0.01),其差异有统计学意义。治疗后两组患者的WOMAC评分、ISOA评分和疼痛评分均显著降低(P<0.01),但治疗组患者的降低程度显著优于对照组(P<0.01),其差异有统计学意义。治疗组患者的总有效率(98.00%)显著优于对照组(82.00%),说明治疗组患者的临床疗效显著优于对照组,差异有统计学意义(P<0.05)。结论:骨氏葆方与膝关节内粘疗法联合应用能够有效改善患者的临床体征,降低患者血沉,是临床上治疗肾虚血瘀型膝重度关节炎的有效方案。
Objective： To study therapeutic effect and security of Gushibao Formula combined with knee sticking therapy on knee function of kidney and blood stasis type of the severe osteoarthritis. Methods： 100 cases of kidney and blood stasis type of severe osteoarthritis,according to the random number table method were divided into treatment group and control group,50 cases in each. Two groups＇ patients were given internal application and health education,etc. On the basis,the control group patients were treated with glucosamine hydrochloride capsule orally. The treatment group＇s patients were treated Gushibao Formula. After continuous 5 weeks treatment,observe the therapeutic effect and clinical symptoms. At the same time monitor the two groups＇ bone type alkaline phosphatase and the changes of calcitonin and blood sedimentation. Results： Two groups＇ blood sedimentation rate after treatment was significantly lower（ P〈0. 01）and the extent of the treatment group＇s patients was significantly better than that of control group（ P〈0. 05）. The difference was statistically significant. But the two groups＇ calcitonin and osseous alkaline phosphatase had no improvement or no statistically significant difference（ P〈0. 05）. In the two groups after treatment,patients＇ main symptoms and signs were significantly lower（ P〈0. 05） and the improvement of the treatment group was significantly better than that of the control group（ P〈0. 01）. The difference was statistically significant. Two groups＇ WOMAC score,ISOA score and pain scores of patients after treatment were significantly lower（ P〈0. 01）,but the extent of the treatment group patients was significantly better than that of the control group（ P〈0. 01）. The difference was statistically significant. The total effec-tive rate of treatment group patients（ 98. 00%） was significantly better than the control group＇s（ 82. 00%）,indicating the clinical curative effect of patients in treatment group was superior to that of the control group and the difference was statistically significant（ P〈0. 05）. Conclusion： Gushibao Formula and sticking therapy can effectively improve the patient＇s clinical signs,reduce the patients＇ blood sedimentation. It is a clinical treatment of kidney and blood stasis type of severe arthritis.
出处
《中华中医药学刊》
CAS
北大核心
2017年第9期2407-2409,共3页
Chinese Archives of Traditional Chinese Medicine
基金
河北省中医药管理局项目(2016166)
关键词
临床疗效
膝关节内粘疗法
骨氏葆方
clinical curative effect
sticking therapy in knee joint
Gushibao Formula
