摘要
目的探讨膝关节感染指标白细胞计数(WBC)、C反应蛋白(CRP)、红细胞沉降率(ESR)、降钙素原(PCT)、白细胞介素-6(IL-6)、中性粒细胞绝对值(GR)的临床价值。方法选取2010年6月至2015年3月112例术前膝关节感染患者作为研究组,选取同时期112例术前、术后均无膝关节感染者作为对照组,均抽取静脉血,观察以上指标在术前及术后第1、3、5、7、14天的水平变化情况。结果研究组术前、术后第1天WBC、CRP、ESR、PCT、IL-6、GR水平均显著高于对照组(P<0.05);术后第3天研究组WBC、CRP、ESR、PCT、IL-6水平均显著高于对照组(P<0.05),术后第5天研究组WBC、CRP、ESR、IL-6含量水平显著高于对照组(P<0.05),其他时间两组比较差异无统计学意义(P>0.05);经Logistic回归分析,WBC、CRP、ESR、PCT、IL-6、GR 6项指标均能预测膝关节感染(P分别为0.005、0.004、0.000、0.002、0.003、0.007)。结论 WBC、CRP、ESR、PCT、IL-6、GR对于早期诊断和预防感染有一定的价值,可扩大样本量进一步研究。
Objective To investigate the clinical value of knee joint infection indexes of white blood cell （WBC）,C reactive protein （CRP）,erythrocyte sedimentation rate （ESR） and procalcitonin （PCT）,interleukin-6 （IL-6） and absolute value of neutrophil （GR）.Methods One hundred and twelve cases of preoperative knee joint infection in our hospital from June 2010 to March 2015 were selected as the research group and contemporaneous 112 cases of no preoperative and postoperative knee joint infection were selected as the control group.The venous blood was collected for observing the changes of the above indexes before operation and at postoperative 1,3,5,7,14 d.Results The levels of WBC,CRP,ESR,PCT,IL-6 and GR before operation and at postoperative 1d in the study group were significantly higher than those in the control group （P〈0.05）;the levels of WBC,CRP,PCT and IL-6 at postoperative 3 d in the study group were significantly higher than those in the control group （P〈0.05）;the levels of WBC,CRP,ESR and IL-6 at postoperative 5 d in the study group were significantly higher than those in the control group （P〈0.05）;the difference at the other time points between the two groups was not statistically significant （P〉0.05）;in the Logistic regression analysis,the six indicators of WBC,CRP,ESR,PCT,IL-6 and GR6 all could predict knee joint infection （P=0.005,0.004,0.000,0.002,0.003,0.007）.Conclusion WBC,CRP,ESR,PCT,IL-6 and GR have certain value for early diagnosis and prevention of infection,and further study on expanded sample size cn carry on.
出处
《国际检验医学杂志》
CAS
2017年第16期2213-2215,共3页
International Journal of Laboratory Medicine
基金
绵阳市科技局2015年度创新科研计划(MK20161306)
关键词
膝关节感染
白细胞
C反应蛋白
红细胞沉降率
降钙素原
白细胞介素-6
中性粒细胞绝对值
knee joint infection
white blood cell
C reactive protein
erythrocyte sedimentation rate
procalcitonin
interleukin-6
neutrophil absolute value
