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盐酸多奈哌齐治疗老年痴呆的效果 被引量:6

Effect of Donepezil in the treatment of senile dementia
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摘要 目的探讨盐酸多奈哌齐治疗老年痴呆的效果。方法选取我院2015年2月~2016年7月收治的81例老年痴呆患者作为研究对象,根据随机综合序贯法分两组。对照组患者(n=40)采用常规治疗,观察组患者(n=41)在此基础上予以盐酸多奈哌齐治疗,对比两组患者的治疗效果。结果治疗前,两组患者的MMSE评分、ADL评分比较,差异无统计学意义(P>0.05)。治疗后,观察组的MMSE评分、ADL评分均明显高于对照组,差异有统计学意义(P<0.05)。观察组总有效率(95.1%)明显高于对照组(77.5%),差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05),症状均较轻微,对症干预后逐步缓解。结论盐酸多奈哌齐治疗老年痴呆的疗效确切,能够有效改善患者的精神状态以及智能水平,预后良好,值得临床推广。 Objective To evaluate the effect of Donepezil in the treatment of senile dementia.Methods Altogether 81 cases of senile dementia patients who were treated in our hospital from February 2015 to July 2016 were selected as study objects,and were randomly divided into two groups according to the comprehensive sequential method.The control group(n =40) was treated with conventional treatment,while the observation group(n =41) was given Donepezil hydrochloride treatment.The treatment effect of two groups was compared.Results Before treatment,MMSE scores and ADL scores were compared in two groups,the differences were not statistically significant(P〈0.05).The total effective rate of observation group was 95.1%,which was significantly higher than that of control group(77.5%),and the difference was statistically significant(P〈0.05).Two groups of adverse reactions were compared,and the difference was not statistically significant(P〈0.05),the symptoms were mild and gradually relieved after symptomatic intervention.Conclusion Donepezil is effective in the treatment of senile dementia and can effectively improve patients′ mental status and intelligence level with good prognosis.which is worthy of clinical promotion.
出处 《中国当代医药》 2017年第24期72-74,共3页 China Modern Medicine
关键词 盐酸多奈哌齐 老年痴呆 精神状态 日常生活能力 Donepezil Senile dementia Mental state Daily life ability
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