摘要
目的探讨幕上及椎管内原始神经外胚层肿瘤的临床特点、诊断、病理表现和治疗进展。方法回顾分析我院一例病理证实的幕上及椎管内原始神经外胚层肿瘤的诊疗经过,并结合相关文献进行复习。结果本例术前行头颅MRI检查呈混杂T_1WI和混杂T_2WI信号,增强后明显不均匀强化;术后病理检查提示均为原始神经外胚层肿瘤。术后行放化疗,一年后发现椎管内病变,MRI检查呈等T_1、稍长T_2信号,增强后明显均匀强化,术后病理检查提示也为原始神经外胚层肿瘤。结论原始神经外胚层肿瘤恶性程度高,易发生转移,影像学无明显特异性,病理检查是可靠的诊断依据,治疗方法优选手术联合放化疗。
Objective To investigate the clinical characteristics,diagnosis,pathological features and treatment of supratentorial and intraspinal primitive neuroectodermal tumor（ PNET） of one case. Methods Diagnosis and treatment of supratentorial and intraspinal PNET in our hospital which proved by pathology were analyzed retrospectively and combined with relevant literature were reviewed. Results The case was mixed signal intensity on T_1 WI,T_2WI,and with uneven and apparent enhancement. It was identified PNET by histopathological examination and immunohistochemical staining. Radiotherapy and chemotherapy were given after surgery. One year later,intraspinal lesions were examined,which were isointense on T_1-weighted images and T_2-weighted images,and with even and apparent enhancement. They were also identified PNET by histopathological examination and immunohistochemical staining. Conclusions PNET is of high malignant degree and prone to transfer,without special image characteristics. The pathological examination is a reliable method for diagnosis of PNET. Optimal treatment is surgery combined with radiotherapy and chemotherapy.
出处
《临床神经外科杂志》
CAS
2017年第4期247-250,共4页
Journal of Clinical Neurosurgery
基金
南京市医学科技发展重点项目(ZKX15034)
关键词
原始神经外胚层肿瘤
幕上
椎管内
primitive neuroectodermal tumor
supratentorial
lintraspinal
