摘要
目的探讨丹参酮ⅡA治疗盐敏感性高血压的效果及其作用机制。方法选取本院门诊于2015年3月至2016年3月收治的98例高血压患者，将其分为盐敏感组（56例）和非盐敏感组（42例），两组患者均采用静脉注射丹参酮ⅡA方式进行治疗，测量两组患者治疗后收缩压、舒张压水平和甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白（HDL）水平变化，比较两组临床疗效、不良反应发生率、治疗前后血压和血脂变化。结果盐敏感组和非盐敏感组总有效率分别为73．21％和52．38％，差异有统计学意义（P〈0．05）。治疗后，盐敏感组收缩压和舒张压水平均显著低于非盐敏感组，差异有统计学意义（P〈0．05）。治疗后盐敏感组TC、TG水平显著低于非盐敏感组，HDL水平显著高于非盐敏感组，差异有统计学意义（P〈0．05）。盐敏感组不良反应发生率（8．93％）与非盐敏感组不良反应发生率（11．90％）比较差异无统计学意义（P〉0．05）。结论丹参酮ⅡA治疗盐敏感性高血压具有较好的临床疗效，可以在临床上广泛推广。
Objective To investigate the effect and action mechanism oftanshinone ⅡA in the treatment of salt sensitive hypertension, Methods From Mar. 2015 to Mar. 2016, a total of 98 hypertension patients in our hospital were divided into salt sensitive group （n=56） and non-salt sensitive group （n=42）. Both groups were given tanshinone ⅡA by intravenous injection. After treatment, the changes of systolic blood pressure （SBP）, diastolic blood pressure （DBP）, triglyceride （TG）, total cholesterol （TC）, and high density lipoprotein （HDL） in the two groups were determined; the clinical effect, the incidence of adverse reactions, changes of blood pressure and blood lipids in the two groups were compared. Results The total effective rate in the salt sensitive group was 73.21%, which was higher than 52.38% in the non-salt sensitive group, with statistically significant difference （P〈0.05）. After treatment, SBP and DBP in the salt sensitive group were significantly lower than those in the non-salt sensitive group, with statistically significant differences （P〈0.05）. After treatment, the levels of TC and TG in the salt sensitive group were significantly lower than those in the non-salt sensitive group, and the level of HDL in the salt sensitive group was significantly higher than that in the non-salt sensitive group, with statistically significant differences （P〈0.05）. There was no statistically significant difference in the incidence of adverse reactions between the salt sensitive group and the non-salt sensitive group （8.93% vs, 11.90%, P〉0.05）. Conclusion Tanshinone ⅡA has good effect in the treatment of salt sensitive hypertension, which can be widely used in clinic.
出处
《国际医药卫生导报》
2017年第18期2850-2852,共3页
International Medicine and Health Guidance News
关键词
丹参酮ⅡA
盐敏感性高血压
临床疗效
平均动脉压
Tanshinone ⅡA
Salt sensitive hypertension
Clinical efficacy
Mean arterial pressure
