摘要
目的:采用偏最小二乘回归(PLSR)算法分析碳青霉烯耐药肺炎克雷伯菌(CR-KP)检出率与抗菌药物使用的相关性,为抗菌药物临床的合理使用提供指导。方法:以不同季度抗菌药物的用药频度(DDDs)为自变量,以同期及滞后不同时期(1~4个季度)CR-KP的检出率为因变量,分别建立PLSR模型,分析CR-KP检出率比抗菌药物使用的滞后性。根据各变量的回归系数,筛选与CR-KP检出率相关性较显著的抗菌药物,明确不同品种对CR-KP检出率的影响。结果:CR-KP的检出率滞后于抗菌药物的使用两个季度,与阿莫西林-克拉维酸、磺苄西林的DDDs正相关性较显著,与伊曲康唑的DDDs负相关性较显著。阿莫西林-克拉维酸、伊曲康唑、磺苄西林的回归系数分别为0.085 2、-0.083 9、0.076 3。结论:PLSR算法可用于同时分析CR-KP检出率与多种抗菌药物使用的相关性,可为CR-KP检出率控制提供依据。
AIM：To provide guidance for the reasonable clinical usage of antibacterial drugs by employing the partial least squares regression（PLSR） algorithm to analyze the correlation between the detection rate of carbapenem-resistant Klebsiella pneumoniae（CR-KP） and the utilization of antibacterial drugs.METHODS：Different PLSR models were established with the defined daily doses（DDDs） of antibacterial drugs in different quarters as independent variables and the detection rate of CR-KP with same and different periods（lagged 1-4 quarters） as dependent variables.The lag time between the detection rate of CR-KP and the utilization of antibacterial drugs was investigated.The antibacterial drugs,which were highly correlated to the detection rate of CR-KP were screened.The influences of the antibacterial drugs on the detection rate of CR-KP were then investigated according to the regression coefficients.RESULTS：The detection rate of CR-KP lagged about two quarters behind the utilization of antibacterial drugs.It was significantly positively correlated with the DDDs of amoxicillin-clavulanic acid and sulbenicillin,while negatively correlated with the DDDs of itraconazole.The regression coefficients of amoxicillin-clavulanic acid,itraconazole and sulbenicillin were 0.085 2,-0.083 9 and 0.076 3,respectively.CONCLUSION：It is effective to employ PLSR algorithm to simultaneously analyze the correlation between the detection rate of CR-KP and the utilization of multiple antibacterial drugs,which provides a new scientific tool for controlling the detection rate of CR-KP.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2017年第8期904-909,共6页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
浙江省公益技术应用研究计划项目(2016C33127)
浙江省中医药科技计划项目(2015ZQ007)
浙江省药学会医院药学专项科研资助项目(2014ZYY10)
关键词
偏最小二乘回归
碳青霉烯耐药肺炎克雷伯菌
耐药性
抗菌药物
用药频度
partial least squares regression
carbapenem-resistant Klebsiella pneumoniae
drug resistance
antibacterial drugs
defined daily doses
