摘要
目的探讨利福喷丁以及利福平治疗肺结核患者的效果以及安全性。方法选取吉林市结核病医院2015年6月至2017年1月收治的90例肺结核患者,两组患者均服用异烟肼、吡嗪酰胺以及乙胺丁醇治疗,将其随机分为观察组以及对照组,分别应用利福喷丁以及利福平治疗,比较两组患者的痰涂片转阴率、空洞闭合情况以及不良反应情况。结果观察组患者在治疗3、5、6个月末的痰转阴率均明显高于对照组,差异均有统计学意义(均P<0.05);观察组患者治疗后病灶的总改善率为91.1%,明显高于对照组的66.7%,差异有统计学意义(P<0.05);观察组患者不良反应发生率为17.8%,明显低于对照组的62.2%,差异有统计学意义(P<0.05)。结论利福喷丁治疗肺结核具有高效、低毒等优点,是治疗肺结核的理想方法。
Objective To investigate the effect of rifapentine and rifampicin in the treatment of patients with pulmonary tuberculosis and safety.Methods 90 cases of pulmonary tuberculosis were selected from June 2015 to January 2017 were tuberculosis hospital of Jilin City,the two groups of patients were taking isoniazid,pyrazinamide and ethambutol treatment,they were randomly divided into observation group and control group,respectively using rifapentine and rifampicin treatment,compared two groups of patients with sputum smear negative rate,cavity closure and adverse reaction.Results Sputum negative patients in the observation group in the treatment of 3,5 and 6 months were significantly higher than the control group,the differences were statistically significant（P〈0.05）;the total improvement after treatment in observation group lesion rate was 91.1%,significantly higher than the control group 66.7%,the difference was statistically significant（P〈0.05）;observation incidence of adverse reactions was 17.8%, significantly lower than the control group 62.2%,the difference was statistically significant（P〈0.05）.Conclusion Rifapentine for the treatment of pulmonary tuberculosis with high efficiency,low toxicity,is an ideal method for the treatment of pulmonary tuberculosis.
出处
《中国药物经济学》
2017年第8期92-93,103,共3页
China Journal of Pharmaceutical Economics
关键词
利福喷丁
利福平
肺结核
Rifapentine
Li Fuping
Pulmonary tuberculosis
