摘要
目的评估微量子宫内膜活检标本在子宫内膜癌及癌前病变筛查中的应用价值。方法收集北京大学人民医院及北京市大兴区人民医院子宫内膜活检标本589例,分别采用环状微量子宫内膜取样器以及分段诊刮获取子宫内膜组织,进行病理学诊断,观察微量子宫内膜活检取样合格率,及其与子宫内膜厚度、年龄的关系,并分析微量子宫内膜活检在子宫内膜癌及癌前病变筛查中的敏感度及特异性,筛选其相对适用人群。结果两家医院微量子宫内膜活检取样合格率为71.5%(421/589),子宫内膜较厚(≥5 mm)、年龄较小(<50岁)的患者更易获得合格的微量子宫内膜活检标本;在微量子宫内膜活检取样合格的标本中检出子宫内膜癌及癌前病变55例,与分段诊刮比较其敏感性为75.3%(55/73),特异性为99.4%(332/334)。结论微量子宫内膜活检标本合格率仍有待提高,相对适用于年轻及子宫内膜较厚的人群,但在取样合格的标本中,其筛查子宫内膜癌及癌前病变特异度较高,表明采用微量子宫内膜活检可以作为高危人群子宫内膜癌筛查的备选方法。
Objective To analyze the application value of micro-endometrial biopsy in screening endometrial carcinoma and precursors lesion. Methods 589 patients were collected from People＇s Hospital of Peking University and Daxing Hospital of Capital Medical University. All the micro-endometrial biopsies were collected by endometrial device before dilatation and curettage. The qualified rate of micro-endometrial biopsy and its relationship with endometrial thicknesses were analyzed, meanwhile, the sensitivity and specificity of screening endometrial carcinoma and precursors were calculated. Results 71.5% （421/589） adequate specimens for diagnosis were obtained by endometrial sampler. It was easier to get qualified endometrial specimen in patients younger than 50 years old and those with thick endometrium. By further analyzing the qtmlified specimens, the sensitivity and specificity of micro-endometrial biopsy for detecting endometrial cancer and its precursors were 75.3% （55/73） and 99.4% （332/334）, respectively. Conclusions The qualified rate of micro-endometrial biopsies was relatively low. However, the sensitivity and specificity of the adequate specimens were high.It can be used for screening endometrial carcinoma and its precursors.
出处
《中国妇产科临床杂志》
CSCD
北大核心
2017年第5期401-403,共3页
Chinese Journal of Clinical Obstetrics and Gynecology
基金
首都卫生发展科研专项项目(2014-3-7122)
关键词
微量子宫内膜活检
子宫内膜癌
癌前病变
筛查
micro-endometrial biopsy
endometrial carcinoma
precancerous lesion
screening
