摘要
通过研究肿瘤抑制率、脾脏指数和胸腺指数、肿瘤切片细胞的形态以及血清中影响因子白细胞介素‐2、肿瘤坏死因子‐α、干扰素‐γ、丙二醛、超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶等指标的变化来考察玉木耳Auricularia cornea提取物体内抗肿瘤作用及其作用机理。结果表明,乙酸乙酯高、低剂量组的抑瘤效果较好分别为39.9%和37.5%;HE染色切片观察各组均出现肿瘤坏死区,高剂量出血坏死面积较低剂量大;与模型组比较,乙酸乙酯组白细胞介素‐2、肿瘤坏死因子‐α、干扰素‐γ含量升高,具有较好的免疫作用。玉木耳提取物具有明显的抗肿瘤作用,其中乙酸乙酯高、低剂量组的抗肿瘤作用最显著,与其增强免疫作用有一定关系。
The anti-tumor activity and mechanism of Auricularia cornea fruiting body extract in H22 bearing mice was studied by detecting the tumor-inhibition rate, spleen and thymus index, content of IL-2, TNF-α, IFN-γ, MDA, SOD, CAT and GSH-Pxin serum and observing pathological section of tumor of H22 mice. The result was that the tumor-inhibition rate of H22 mice treated with high dose and low dose of ethyl acetate extract was 39.9% and 37.5% respectively; the necrosis was found in the tumor of the a treating groups, and the necrosis area in high dose treating group of ethyl acetate extract was obviously larger than that in low dose treating group through observing the tumor section stained with HE. Compared with model group, ethyl acetate extract could enhance immune activity and increase the content of IL-2, TNF-α, IFN-γ significantly. It is proved that Auricularia cornea fruiting body extract has potential anti-tumor effect
出处
《菌物学报》
CAS
CSCD
北大核心
2017年第9期1289-1298,共10页
Mycosystema
基金
长江学者和创新团队发展计划项目(IRT‐15R25)
平台项目(吉林省高等学校高端科技创新平台建设)~~
关键词
玉木耳
抗肿瘤
免疫调节
抗氧化
Auricularia cornea, anti-tumor, the immune regulation, anti-oxidation
