摘要
目的分析脾氨肽口服冻干粉联合阿奇霉素治疗小儿肺炎支原体感染的疗效及对免疫功能的影响。方法以2013年5月—2016年6月开封市儿童医院诊治的肺炎支原体感染患儿106例为研究对象,根据入组的先后顺序分为观察组和对照组,每组53例。对照组患儿采用阿奇霉素序贯治疗,观察组在对照组的基础上加用脾氨肽口服冻干粉,均治疗3周。比较两组的临床疗效、T细胞亚群(CD4+、CD8+、CD4+/CD8+)水平、细胞因子(IL-10、IL-17、TGF-β1)水平及安全性。结果观察组的临床总有效率为94.39%,显著高于对照组的79.25%,差异有统计学意义(P<0.05)。治疗后,两组的CD4+、CD4+/CD8+较治疗前显著升高(P<0.05),且观察组的显著高于对照组,差异有统计学意义(P<0.05);CD8+较治疗前显著降低(P<0.05),且观察组的显著低于对照组,差异有统计学意义(P<0.05)。治疗后,两组的IL-10、IL-17、TGF-β1水平均较治疗前显著降低(P<0.05),且观察组的显著低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义。结论脾氨肽口服冻干粉联合阿奇霉素治疗小儿肺炎支原体感染的临床疗效显著,安全可靠,可显著提高机体的细胞免疫功能,同时降低免疫损伤。
Objective To investigate the clinical effect of Spleen Aminopeptide Oral Lyophilized Powder on mycoplasma pneumonia in children and its influence in immune function. Methods Totally 103 cases of children infected with mycoplasma pneumonia from May 2013 to June 2016 were selected and divided into observation group and control group, with 53 cases in each group. The control group were treated with azithromycin, and observation group were treated with azithromycin combined with Spleen Aminopeptide Oral Lyophilized Powder. The clinical effect, T cell subgroup （CD4^＋, CD8^＋, CD4^＋/CD8^＋） levels, serum cytokine levels （IL-10, IL-17, TGF-β1） and salty were compared. Results The total effective rate of the observation group was 94.39%, which was significantly higher than that of the control group of 79.25% （P 〈 0.05）. After treatment, the levels of CD4^＋, CD4^＋/CD8^＋ in two groups were significantly higher than those before treatment （P 〈 0.05）, and the levels of CD4^＋, CD4^＋/CD8^＋ in observation were higher than those in control group significantly （P 〈 0.05）. The levels of CD8^＋, IL-10, IL-17, TGF-β1 in two groups were significantly lower than before treatment （P 〈 0.05）, and those indexes in observation were lower than those in control group, the difference was statistically significant （P 〈 0.05）. Conclusion Azithromycin combined with Spleen Aminopeptide Oral Lyophilized Powder has remarkable clinical effect on mycoplasma pneumonia in children, which is cecurity and reliable, and can improve the cellular immune function and reduce the immune injury.
出处
《药物评价研究》
CAS
2017年第7期950-954,共5页
Drug Evaluation Research
关键词
肺炎支原体
小儿
脾氨肽口服冻干粉
阿奇霉素
免疫
mycoplasma pneumonia
children
Spleen Aminopeptide Oral Lyophilized Powder
azithromycin
immune
