摘要
目的分析阻塞性睡眠呼吸暂停低通气综合征(OSAHS)血栓前状态的危险因素,为OSAHS患者静脉血栓栓塞症的预防提供参考和借鉴。方法选取2014年6月至2016年7月在新疆医科大学附属第一医院经多导睡眠监测(PSG)明确诊断为OSHAS并进行了凝血、血栓与纤溶检测及炎症因子组合测定,同时排除存在其他可能影响凝血功能因素的患者共238例。其中符合血栓前状态参考标准的患者56例(即血栓前状态组),剩余182例患者凝血及血栓与纤溶检测不满足参考标准,从中随机抽取59例患者为对照组(即非血栓前状态组)。比较两组患者年龄、性别、体重指数(BMI)、睡眠呼吸暂停低通气指数(AHI)、白细胞介素-6(IL-6)、合并慢性阻塞性肺疾病(简称慢阻肺)和合并高血压的状况。结果非条件Logistic回归分析显示OSAHS血栓前状态的危险因素有年龄(OR=1.202,95%CI:1.107~1.305)、IL-6(OR=1.127,95%CI:1.014~1.252)、AHI(OR=1.151,95%CI:1.055~1.256)、合并慢阻肺(OR=4.749,95%CI:1.046~21.555)。结论年龄、AHI、IL-6、合并慢阻肺可能是OSAHS患者血栓前状态的危险因素,其中合并慢阻肺可能是最重要的危险因素。
Objective To analyze the risk factors of prethrombotic state of obstructive sleep apnea and hyponea syndrome （OSAHS）, providing basis and reference for the prevention of prethrombotic state of OSAHS. Methods Two hundred and thirty-eight patients excluding the presence of possible effects of coagulation factors from June 2014 to July 2016 were diagnosed as OSAHS by polysomnography （PSG） and underwent coagulation, thrombosis, fibrinolysis, and inflammatory factors testing. Fifty-six patients met the standard of prethrombotic state （prethrombotic state group） and 59 patients randomly selected from the remaining 182 patients did not meet the standard （non-prethrombotic state group）. The age, sex, body mass index （BMI）, sleep apnea and hypopnea index （AHI）, interleukin-6 （IL-6）, complicating chronic obstructive pulmonary disease （COPD） and hypertension were compared between two groups. Results Non conditional Logistic regression analysis showed that the risk factors of prethrombotic state of OSAHS were age （OR=1.202, 95%CI： 1.107 to 1.305）, IL-6 （OR=1.127, 95%CI： 1.014 to 1.252）, AHI （OR=1.151, 95%CI： 1.055 to 1.256）, and complicating COPD （OR=4.749, 95%CI： 1.046 to 21.555）. Conclusion Age, AHI, IL-6, and complicating COPD may be the risk factors of prethrombotic state of OSAHS, among which complicating COPD may be the most important risk factor.
出处
《中国呼吸与危重监护杂志》
CAS
CSCD
北大核心
2017年第5期469-473,共5页
Chinese Journal of Respiratory and Critical Care Medicine
