摘要
随着中国进入老龄化社会,人口生育政策逐步放开,揭示脑与行为毕生发展的一般规律和常规模式(常模)正成为公共卫生和人口健康领域的重大基础需求.本文介绍"中国彩巢计划"(Chinese Color Nest Project—CCNP)这一在全国范围内分期分步地开展的项目规划,在10年(2013~2022年:http://zuolab.psych.ac.cn/colornest.html)内CCNP将积累毕生发展各年龄段的心理行为与脑影像样本,基于加速纵向实验设计方法建立中国人脑毕生发展的常模轨线.作为CCNP的发育项目"成长在中国"(dev CCNP:Growing Up in China)这一学龄儿童青少年脑与行为生长曲线项目,dev CCNP已经完成对重庆北碚区192名健康儿童青少年(6~18岁)的5年追踪.初步的研究结果表明,dev CCNP在实验设计、样本采集策略、数据获取和存储、初步发现和数据共享等方面具备长期实施的可行性,我国应及早部署开展儿童青少年的脑与认知生长曲线常模的大规模脑科学研究计划,提升中国在脑科学与医疗健康研究领域的国际实力和影响力,革新脑疾病临床实践.
To face the challenges of keeping healthy in increasing population sizes of both ageing and developing people in China, a fundamental request from the public health is the development of lifespan normative trajectories of brain and behavior. This paper introduces the Chinese Color Nest Project（CCNP 2013–2022）, a large-scale ten-year program of modeling brain and behavioral trajectories for human lifespan（6–85 years old）. We plan to gradually collect the behavioral and brain imaging data at ages across the lifespan on nationwide and depict the normal trajectory of Chinese brain development across the lifespan, based on the accelerated longitudinal design in the coming next 10 years starting at 2013. Various psychiatric disorders have been demonstrated highly relevant to abnormal events during the neurodevelopment regarding their onset ages of first episodes. Therefore, delineation of normative growth curves of brain and cognition in typically developing children is extremely useful for monitoring, early detecting and intervention of various neurodevelopmental disorders. In this paper, we detailed the developing part of CCNP, dev CCNP. It tracked 192 healthy children and adolescents（6–18 years old） in Beibei district of Chongqing for the first 5 years of the full CCNP cohort（2013–2017）. To demonstrate the feasibility of implementing the long-term follow-up of CCNP, we here comprehensively document dev CCNP in terms of its experimental design, sample strategies, data acquisition and storage as well as some preliminary results and data sharing roadmap for future. Specifically, we first describe the accelerated longitudinal sampling design as well as its exact ratioof sample dropping off during the data collection. Second, we present several initial findings such as canonical growth curves of cortical surface areas of a set of well-established large-scale functional networks of the human brain. Finally, together with records generated by many psychological and behavioral tests, we will provide an individual growing-up report for each family participating the program, initiating the potential guidance on the individual academic and social development. The resources introduced in the current work can provide first-hand data for a series of coming Chinese brain development studies, such as Chinese Standard MRI Brain Templates, Normative Growth Curves of Chinese Brain and Cognition as well as Mapping of Language Areas in Chinese Developing Brain. These would not only offer normative references of the atypical brain and cognition development for Chinese population but also serve as a strong force on accelerating the pace of integrating Chinese brain development into the national brain program or Chinese Brain Project.
出处
《科学通报》
EI
CAS
CSCD
北大核心
2017年第26期3008-3022,共15页
Chinese Science Bulletin
基金
国家自然科学基金重点国际合作交流项目(81220108014)
中国科学院重点部署项目(KSZD-EW-TZ-002)
国家重点基础研究发展计划(2015CB351702)
中国科学院-荷兰科研组织国际合作项目(153111KYSB20160020)
北京市科技重大专项(Z171100000117012)
北京市国家重大研发计划匹配(Z161100002616023)资助
关键词
中国彩巢计划
生长曲线
脑发育
脑成像
连接组
Chinese Color Nest Project
growth curve
brain development
brain mapping
connectome
