摘要
报告1例Dowing-Degos病。患者女,45岁。因颈部、乳房下及外阴色素性斑丘疹30余年就诊。患者母亲和2个弟弟均有类似疾病。皮损组织病理检查显示表皮突延长呈线状或鹿角状,基底层色素明显增加。真皮浅层血管周围少量淋巴细胞和组织细胞浸润,并可见较多噬色素细胞。结合临床及组织病理,诊断为Dowling-Degos病。给予异维A酸10 mg每日2次口服,2个月后皮损有所好转。
A case of Dowling-Degos disease is reported. A 45-year-old female presented with pigmented papules and mac- ules on her neck, flexural aspect of breasts, and perineal areas. Similar lesions were noted in her mother and 2 brothers. Histopathological examination revealed elongated branched rete ridges with hyperpigmentation in the basal layer. Perivascular infiltration of lymphocytes and melanophages could be seen in the upper dermis. Coupling with the clinical and histopathlogi- cal features, the diagnosis of Dowling-Degos disease was made. The lesions were partially improved following the treatment with oral isotretinoin 20 mg/d for 2 months.
出处
《临床皮肤科杂志》
CSCD
北大核心
2017年第10期700-702,共3页
Journal of Clinical Dermatology
关键词
Dowling-Degos病
pigmented anomaly, reticular, flexure
Dowling-Degos disease
