摘要
钩端螺旋体病(简称钩体病)是由致病性钩端螺旋体(简称钩体)引起的一种急性人兽共患传染病,给当地人民健康和畜牧业生产造成了严重的影响.因此,钩体病越来越引起人们的重视.随着生物技术的发展,研究人员已在钩体的致病性、分子流行趋势及遗传进化机制等方面取得重大突破,本文就近些年国内外致病性钩体分子进化和分型的研究进展作一综述,以期为未来钩体的分子流行病学监测和新疫苗研制等工作提供参考.
Leptospirosis is recognized as an important emerging zoonotic disease caused by pathogenic Leptospira spp.and has a serious impact on people′s health and animal husbandry.Therefore, it has attracted more and more attention.With the development of biotechnology, major breakthroughs have been made in the fields of pathogenicity, molecular epidemic features and evolution mechanism of Leptospira.In this review, we summarize progress in evolution and molecular typing of Leptospira at home and abroad in order to provide a reference for further research on molecular epidemiological surveillance and new vaccine development.
出处
《中华微生物学和免疫学杂志》
CAS
CSCD
北大核心
2017年第8期624-627,共4页
Chinese Journal of Microbiology and Immunology
基金
国家科技重大专项课题“重大新药创制”(2013ZX09304101)
国家自然科学基金(81471968)
中国食品药品检定研究院学科带头人基金(2013X4)
医学微生物资源子平台运行与服务(NIMR-2017-2)