摘要
目的研究给予不同剂量丙泊酚中/长链脂肪乳注射液对七氟醚全麻下行口腔治疗术的患儿苏醒期躁动的影响。方法选择南开大学附属口腔医院2016年8月—12月拟在全麻下行多发龋齿充填治疗术的患儿90例,随机分为三组:术毕,S组单次静注0.1 ml/kg 0.9%氯化钠注射液;A组单次静注1 mg/kg丙泊酚中/长链脂肪乳注射液;B组术毕前3 min静滴丙泊酚中/长链脂肪乳注射液1 ml/kg,术毕再次静滴1 ml/kg,比较三组患儿术后30 min内每10 min躁动发生率、躁动评分峰值以及苏醒时间和恢复室停留时间以及不良反应结果。结果A、B两组躁动发生率在进入复苏室即刻(0 min)和10 min时均低于S组,差异有统计学意义(P<0.001),在20 min和30 min时,B组发生率低于S组和A组,差异有统计学意义(P<0.05),S组和A组差异无统计学意义(P>0.05)。术后30 min内躁动评分峰值B组<A组<S组,差异有统计学意义(P<0.05)。A、B两组苏醒时间都延长,但复苏室停留时间差异无统计学意义(P>0.05),三组均未发生不良反应。结论术毕注射高剂量丙泊酚中/长链脂肪乳注射液能有效降低躁动发生率与严重程度,延长苏醒时间,但不增加复苏室停留时间,不增加不良反应,安全性较好。
Objective To explore the effect of injection of different doses of propolfol medium/long chain fat emulsion injection after sevoflurane anesthesia to prevent emergence agitation. Methods In this prospective controlled trial, 90 children undergoing odontopathy curing under sevoflurane anesthesia in Tianjin Stomatology Hospital affiliated to Nankai University from August to December 2016 were randomly assigned to three groups receiving ether 0.1 ml/kg 0.9% Sodium Chloride ~Group S）, propofol medium/long chain fat emulsion injection 1 mg/kg bolus （Group A） by once and propofol medium/long chain fat emulsion injection 1 mg/kg （B group） by twice 3 rain before the surgery was finished. The study drugs were administered on the end of surgery for lmg/kg. The incidence and severity （the peak PAED score） of EA were documented every 10 min within 30 min. Times to emergence, postanesthesia care unit （PACU） discharge and incidence of nausea/vomiting were assessed. Results The incidence of EA was lower in group A and group B than in group S at 0, 10 rain after arrival at the post-anaesthesia care unit （P〈0.001） and it was lower in group B than in group S and group A at 20,30 rain （P〈0.05）,but with no difference between group S and group A （P〉0.05）. There were statistical differences in the peak PAED scores with group B〈group A〈group S （P〈0.05）. The time for emergence of Group B and A was significantly longer than that of Group S. The PACU discharge time and the adverse effect were similar in three groups （P〉0.05）. There were no adverse reactions in three groups. Conclusion Administration of a high of dosage of propofol medium/long chain fat emulsion injection at the end of anesthesia reduces the incidence and severity of EA. There is a small increase in emergence time, but no delay in postanesthesia care unit （PACU） discharge. There is no increase of adverse reactions and the safety is good.
出处
《继续医学教育》
2017年第9期145-148,共4页
Continuing Medical Education
