摘要
目的:总结并描述免疫球蛋白4(IgG4)相关桥本氏甲状腺炎的研究现状。方法:收集近年来国内外对于IgG4相关疾病及IgG4相关甲状腺疾病等文献并做综述。结果:IgG4桥本氏甲状腺炎是一种新的桥本病亚型,这一类型有独特的特点:血浆IgG4水平明显升高,IgG4/IgG比例增加,甲状腺组织具有严重的淋巴细胞浸润、密集的纤维化、滤泡细胞变性、消失等改变,临床上呈现出患病年龄偏低、男性患病比例较高、病情进展更加迅速、更易出现甲状腺功能减低(甲减)等特点。结论:这种新的HT亚型的发现开启了对桥本病崭新的认识,对桥本病的诊断、治疗、预后具有重大意义。
Objective：To summarize and describe the research progress of IgG4 related hashimoto＇s thyroiditis.Methods：Collect domestic and international publications involving the IgG4-related diseases and IgG4-related thyroiditis diseases in recent years and make a review.Results：IgG4-related hashimoto＇s thyroiditis is a new subtype of hashimoto＇s thyroiditis.The unique subtype has distinct features：serum IgG4 concentration and the ratio of IgG4/IgG elevated,a higher grade of stromal fibrosis,lymphoplasmacytic infiltration,and follicular cell degeneration,clinically,IgG4 hashimoto＇ s thyroiditis was association with younger age and low female-male ratio,more rapid progress and more hypothyroidism.Conclusion：The new finding is one of the greatest revolutions in our understanding,it has great significance to clinical diagnosis,treatment and prognosis.
作者
魏亚玲
李昭英
WEI Yaling LI Zhaoying(Shanxi Medical University, Taiyuan 030001, China The First Hospital of Shanxi Medical University, Taiyuan 030001, China)
出处
《临床医药实践》
2017年第9期685-688,720,共5页
Proceeding of Clinical Medicine
