摘要
目的:评价复方甘草酸苷与还原型谷胱甘肽联用对药物性肝损伤患者肝功能指标改善作用的疗效。方法:选取2015年1月—2016年6月间收治的药物性肝损伤患者76例临床资料,采用随机分组法将其分为治疗组和对照组,每组38例;对照组患者给予常规药物治疗,治疗组患者在对照组基础上加用还原型谷胱甘肽和复方甘草酸苷治疗;评价两组患者用药2周时的总有效率和治疗前后肝功能各指标的变化情况。结果:治疗14 d后治疗组患者的总有效率为94.74%高于对照组为44.74%(P<0.05),血清总胆红素(TBIL)、谷草转氨酶(AST)、谷丙转氨酶(ALT)测定值的绝对比值均优于对照组(P<0.05)。结论:采用复方甘草酸苷与还原型谷胱甘肽联用治疗药物性肝损伤患者,改善了肝功能指标和预后,临床疗效较为显著。
Objective： To evaluate the clinical efficacy of improving liver function using compound glycyrrhizin combined with glutathione in patients with drugs liver damages. Methods： 76 patients with drug- induced liver injury during January 2015 and June 2016 were collected and randomly divided into treatment group and control group （38 cases in each group）. Compared with the routine treatment in the control group, the patients in the treatment group be- sides of the routine treatment were under the intravenous use of Reduced Glutathione and Compound Glycyrrhizin. The amounts of the two groups in the total rates and indexes of the liver functions before and after treatments were checked and analyzed in two weeks. Results： In 14 days, the total effective rate of the treatment group was 94.73% much higher than that of 44.74% in the control group at the level of P〈 0.05. The ratio values of the bilirubin （TBIL）, aspartate ami- notransfcrase（AST） and serum alanine aminotransferase（ALT） of the treatment group were superior to those of the con- trol group （P〈0.05）. Conclusion： The recoveries of liver functions could be obviously produced and promoted by the combination of glycyrrhizin and glutathione in patients with drug-induced liver injury. Therefore, the treatment effects of glutathione and compound glycyrrhizin reduction in patients with drug-induced liver injuries could be significantly used to improve the recoveries of liver functions in clinics.
出处
《抗感染药学》
2017年第5期995-997,共3页
Anti-infection Pharmacy
