摘要
目的探究糖皮质激素序贯治疗COPD急性加重期的临床疗效及用药安全。方法选择2016年2月—2017年2月我院收治的60例COPD急性加重期患者作为研究对象。将其分为两组。对照组予以短期全程静脉甲基强的松龙治疗,观察组先予以甲基强的松龙,治疗3d后,在序贯口服强的松片治疗4 d。治疗1周后,对比两组患者的临床疗效和药物不良反应发生情况。结果观察组临床总有效率为93.3%,对照组总有效率为90.0%,两组对比,差异无统计学意义(P>0.05)。观察组药物不良反应发生率为6.7%,低于对照组的26.7%,差异具有统计学意义(P<0.05)。结论 COPD急性加重期时开展糖皮质激素序贯治疗的临床疗效确切,且用药安全性更高。
Objective To investigate the clinical efficacy and safety of sequential therapy with glucocorticoid in acute exacerbation of COPD, Methods 60 patients with acute exacerbation of COPD treated in our hospital from February 2016 to February 2017 were selected as the subjects and were divided into two groups. The control group was treated with shortterm whole intravenous methylprednisolone, the observation group was treated with methylprednisolone, the treatment of 3 days, the sequential oral prednisone tablets, the treatment of 4 days. After 1 week of treatment, the clinical efficacy and adverse drug reactions of the two groups were compared. Results The total effective rate of the observation group was 93.3%, and the total effective rate of the control group was 90%. The difference between the two groups was not statistically significant （P 〉 0.05）. The incidence of adverse drug reactions in the observation group was 6.7%, which was lower than 26.7% in the control group, and the difference was statistically significant （P 〈 0.05）. Conclusion The clinical effect of sequential therapy of glucocorticoid in acute exacerbation of COPD is accurate, and its safety is higher.
作者
郑小兵
ZHENG Xiaobing(Department of Pulmonary Disease, Kunshan Traditional Chinese Medicine Hospital, Kunshan Jiangsu 215300, China)
出处
《中国继续医学教育》
2017年第21期183-185,共3页
China Continuing Medical Education
关键词
糖皮质激素
序贯治疗
COPD急性加重期
临床疗效
用药安全
glucocorticoid
sequential therapy
acute exacerbation ofCOPD
clinical efficacy
safety of medication
